Wartungsarbeiten: Am 16.01.2025 von ca. 8:00 bis 11:00 Uhr steht Ihnen das System nicht zur Verfügung. Bitte stellen Sie sich entsprechend darauf ein.
 

The role of liver in leptin metabolism in experimental nephrotic syndrome

Simple item page
dc.contributor.authorAhmed, Mohamed Mahmoud
dc.contributor.authorAmin, Ahmed Ibrahim
dc.contributor.authorFahmi, Abdelgawad Ali
dc.contributor.authorHabib, Dawoud Fakhry
dc.contributor.authorKholousy, Naglaa Mohamed
dc.contributor.authorShalaby, Mostafa
dc.contributor.authorShanab, Asem Metwally Abo
dc.date.accessioned2012-09-20T12:33:56Z
dc.date.available2012-09-20T12:33:56Z
dc.date.issued2012-09-20
dc.description.abstractLeptin is a hormone influencing food intake, energy expenditure and body weight. It is pro-duced by adipocytes, exerts its effects on brain, endocrine pancreas and other organs by acti-vating trans-membrane receptors and is cleared from plasma mainly by the kidneys. Several studies have suggested that leptin's effects on metabolism are mediated by the liver. Our aim was to evaluate the role of the liver in the metabolism of leptin by comparing the serum leptin level in the portal vein with that in inferior vena cava and to study the relationship between leptin and lipoprotein levels in healthy and nephrotic rats. Experimental nephrotic syndrome was conducted in rats by intraperitoneal injection of the supernatant from the kidney suspen-sion obtained by previous unilateral nephrectomy of the same rat and complete Freund's adju-vant. There was a highly significant rise in leptin and lipid profile levels in the nephrotic rats compared with the normal rats. A highly significant increase in leptin in the inferior vena cava was detected compared with the level in the portal veins of nephrotic rats, while insignificant difference was observed in normal rats. This work has stressed the role of liver in leptin and lipid metabolism in nephrotic rats.en
dc.identifier.urihttp://hdl.handle.net/2003/29635
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-5134
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal ; Vol. 10, 2011en
dc.subjectapolipoproteinsen
dc.subjectleptinen
dc.subjectlipidsen
dc.subjectlipoproteinsen
dc.subjectliveren
dc.subjectnephrotic syndromeen
dc.subjectratsen
dc.subject.ddc610
dc.titleThe role of liver in leptin metabolism in experimental nephrotic syndromeen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Fakhry Habib_09012012_proof_corrected.pdf
Size:
106.1 KB
Format:
Adobe Portable Document Format
Description:
DNB
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.85 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Original Articles