New bioactive triterpenoids and antimalarial activity of Diospyros rubra Lec.
Loading...
Date
2010-02-09T15:58:09Z
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The first investigation of the chemical constituents and bioactivities of Diospyros rubra Lec. is reported. D. rubra extracts were screened for antimicrobial, antimalarial and cytotoxic activities.
They were only shown to be active antimalarials. The extracts with good antimalarial activity were isolated and extensively purified to give lupeol (1), lupenone (2), betulin (3), lupeol acetate (4), 28-O-acetylbetulin (5), β-sitosteryl-3-O-β-D-glucopyranoside (6) and a mixture of β-sitosterol and stigmasterol. Some of the isolates were tested for antimicrobial
and cytotoxic actions. Betulin (3) displayed antimicrobial activity against Streptococcus pyogenes with a minimum inhibitory concentration (MIC) of 85 μg/mL. Interestingly, bioactive fractions all selectively exerted some antimicrobial activity against Corynebacterium diphtheriae
NCTC 10356 with the MIC range of 64–256 μg/mL. The study provides data to support
the medicinal importance of the D. rubra.
Description
Table of contents
Keywords
antimalarial and cytotoxic activities, antimicrobial, Diospyros rubra Lec., triterpenoids