Comparison of melatonin and curcumin effect at the light and dark periods on regeneration of sciatic nerve crush injury in rats
Loading...
Date
2019-08-21
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Being one of the acute clinical problems, peripheral nerve injury can bring about a number of consequences in-
cluding severe disability, redu
ced Quality of life (QOL) and immense costs. Currently, melatonin and curcumin
are widely applied because of their immunomodulatory, anti-inflammatory, neuro-protective and antioxidant prop-
erties. The present stud
y aims to compare the effects of melatonin and curcumin during light and dark periods on
sciatic nerve crush injury repair. Acco
rdingly, rats received IP injections
of curcumin (100 mg/kg) and melatonin
(10 mg/kg) over two periods of light (9:00 a.m.) and dark (9
:00 p.m.) for 4 weeks. In order to evaluate rats, func-
tional (walking track analysis and
electrophysiological measurements),
histomorphometric and gastrocnemius
muscle mass investigations were administered. No statis
tically significant difference
was identified between dark
and light curcumin groups while curcumin groups displayed better results than did melatonin groups. In addition,
dark melatonin group displayed better results than the light melatonin. On the whole, this study found that mela-
tonin and curcumin can be used to quicken neural recovery and help treat nerve injury. It was also found that better
neuroregeneration or nerve regeneration was induced when ra
ts were treated by melatonin during the dark period
while effects and injection time did not
correlate in curcum
in application.
Description
Table of contents
Keywords
Melatonin, curcumin, nerve injury, anti-inflammatory, antioxidant, crush