Inhibition of prostate cancer cell line (PC-3) by anhydrodihydroartemisinin (ADHA) through caspase-dependent pathway
| dc.contributor.author | Ahmad, Faiz | |
| dc.contributor.author | Sarder, Amit | |
| dc.contributor.author | Gour, Rajesh | |
| dc.contributor.author | Karna, Shibendra Kumar Lal | |
| dc.contributor.author | Arora, Priya | |
| dc.contributor.author | Kartha, P. Ravindranathan | |
| dc.contributor.author | Pokharel, Yuba Raj | |
| dc.date.accessioned | 2020-12-07T16:32:41Z | |
| dc.date.available | 2020-12-07T16:32:41Z | |
| dc.date.issued | 2020-05-11 | |
| dc.description.abstract | Cancer is a generic term for a large group of diseases characterized by the growth of abnormal cells, which is the second leading cause of death globally. To treat cancer, currently, a number of anticancer drugs belonging to various classes chemically are available. The discovery of artemisinin and its derivatives such as artesunate, arteether, and artemether became a milestone in the cure for malaria. Here, we report the anti-cancer property of anhydrodihydroartemisinin (ADHA) - a semisynthetic derivative of artemisinin against prostate cancer cell line PC-3. ADHA was found to be inhibiting growth of PC-3 cells. ADHA was also found to be inhibiting migration of PC-3 cells. At molecular level, ADHA was found to be inhibiting the expression of c-Jun, p-c-Jun, p-Akt and NF-κB and activated caspase 3 and 7. The results show that ADHA like few other artemisinin derivatives hold potential to be used as an anti-cancer agent against prostate cancer cells. | en |
| dc.identifier.citation | https://www.excli.de/index.php/excli/article/view/2290 | de |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/39852 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-21743 | |
| dc.language.iso | en | |
| dc.publisher | IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund | de |
| dc.relation.ispartofseries | EXCLI Journal;Vol. 19. 2020, p. 613-619 | |
| dc.subject | Anhydrodihydroartemisinin | en |
| dc.subject | PC-3 | en |
| dc.subject | Apoptosis | en |
| dc.subject | Caspase 3 | en |
| dc.subject | Caspase 7 | en |
| dc.subject | c-Jun | en |
| dc.subject | Akt | en |
| dc.subject | NF-κB | en |
| dc.subject.ddc | 610 | |
| dc.title | Inhibition of prostate cancer cell line (PC-3) by anhydrodihydroartemisinin (ADHA) through caspase-dependent pathway | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 | |
| eldorado.secondarypublication | true |