Evaluation of glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism and susceptibility to type 2 diabetes mellitus
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Date
2017-11-06
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Abstract
It is well established that type 2 diabetes mellitus (T2DM) is associated with oxidative stress and
glutathione S- transferases (GSTs) protect cells against oxidative stress. The missense
substitution Ile105Val (rs1695) of the glutathione S-transferase P1 (GSTP1, OMIM: 134660) results
from an A/G base substitution at nucleotide 313. Many studies have evaluated the correlation
between the rs1695 polymorphism and T2DM, but the results remain inconclusive. The aim of the
present meta-analysis was to investigate the association between GSTP1 Ile105Val polymorphism and
the susceptibility risk of T2DM. Eligible studies (published before August 2017) were identi- fied
in several databases. The heterogeneity between studies was evaluated with the chi-square based Q
test and the I2 test. The strengths of the association were assessed by pooled odds ratios (ORs)
and the corresponding 95 % confidence interval (95 % CI) using either a fixed or random-effects
models. Eighteen studies documenting a total of 2595 T2DM cases and 2888 controls were included in
this meta-analysis. In the overall analysis there was no significant association between the rs1695
polymorphism and the risk of T2DM. The subgroup analyses stratified by ethnicity, publication year
and sample size did not reveal significant association between the study polymor- phism and the
risk of T2DM and any sources contributing to the substantial heterogeneity between studies. The
present meta-analysis suggested that there was significant heterogeneity between studies.
Considering some limi tations of our meta-analysis, further large-scale studies should be done to
reach a more comprehensive understanding.
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Keywords
Susceptibility, Heterogeneity, Risk, Diabetes mellitus, Genetic polymorphism