Heme oxygenase effect on mesenchymal stem cells action on experimental Alzheimer's disease

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dc.contributor.authorAbdel Aziz, M. T.
dc.contributor.authorAtta, H. M.
dc.contributor.authorSamer, H.
dc.contributor.authorAhmed, H. H.
dc.contributor.authorRashed, L. A.
dc.contributor.authorSabry, D.
dc.contributor.authorAbdel Raouf, E. R.
dc.contributor.authorALKaffas, M. A.
dc.date.accessioned2014-03-11T09:42:32Z
dc.date.available2014-03-11T09:42:32Z
dc.date.issued2013-09-03
dc.description.abstractThe objective is to evaluate the effect of heme oxygenase-1 (HO-1) enzyme inducer and inhibitor on Mesenchymal Stem Cells (MSCs) in Alzheimer disease. Materials and Methods: 70 female albino rats were divided equally into 7 groups as follows: group 1: healthy control; group 2: Aluminium chloride induced Alzheimer disease; group 3: induced Alzheimer rats that received intravenous injection of MSCs; group 4: induced Alzheimer rats that received MSCs and HO inducer cobalt protoporphyrin; group 5: induced Alzheimer rats that received MSCs and HO inhibitor zinc protoporphyrin; group 6: induced Alzheimer rats that received HO inducer; group7: induced Alzheimer rats that received HO inhibitor. Brain tissue was collected for HO-1, seladin-1 gene expression by real time polymerase chain reaction, heme oxygenase activity, cholesterol estimation and histopathological examination. Results: MSCs decreased the plaque lesions, heme oxygenase induction with stem cells also decreased plaque lesions however there was hemorrhage in the brain. Both heme oxygenase inducer alone or with stem cells increased seladin-1 expression and decreased cholesterol level. Conclusion: MSCs alone or with HO-1 induction exert a therapeutic effect against the brain lesion in Alzheimer’s disease possibly through decreasing the brain cholesterol level and increasing seladin-1 gene expression.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/32958
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-11528
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal ; Vol. 12, 2013en
dc.subjectAlzheimer's diseaseen
dc.subjectstem cellen
dc.subjectheme oxygenaseen
dc.subject.ddc610
dc.titleHeme oxygenase effect on mesenchymal stem cells action on experimental Alzheimer's diseaseen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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