Atrial natriuretic peptide gene - a potential biomarker for Long QT syndrome

dc.contributor.authorQureshi, Sameera Fatima
dc.contributor.authorAli, Altaf
dc.contributor.authorVenkateshwari, Ananthapur
dc.contributor.authorRao, Hygriv
dc.contributor.authorJayakrishnan, M. P.
dc.contributor.authorNarasimhan, Calambur
dc.contributor.authorShenthar, Jayaprakash
dc.contributor.authorThangaraj, Kumarasamy
dc.contributor.authorNallari, Pratibha
dc.date.accessioned2014-11-25T10:05:01Z
dc.date.available2014-11-25T10:05:01Z
dc.date.issued2014-08-15
dc.description.abstractThis study highlights the possible implication of NPPA (natriuretic peptide precursor A) gene in the etiology of Long QT syndrome (LQTS) by population-based as well as familial study. Three SNPs of NPPA- C-664G, C1363A and T1766C were examined by molecular analyses in LQTS, controls and first degree relatives (FDRs). This study revealed a possible association of 1364 C>A SNP ā€˜Cā€™ allele with LQTS (p = 0.0013). All three SNPs were in tight linkage disequilibrium. The familial study highlights the association of NPPA SNP with cLQTS and implicating it as a potential biomarker in South Indian population.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/33699
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-6728
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal ; Vol. 13, 2014en
dc.subjectatrial natriuretic peptideen
dc.subjectLong QT syndromeen
dc.subjectcardiogenesisen
dc.subjectbiomarkeren
dc.subjectpolymorphismsen
dc.subject.ddc610
dc.titleAtrial natriuretic peptide gene - a potential biomarker for Long QT syndromeen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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