Post-operative acute kidney injury in non-suprainguinal vascular surgery patients with a pre-operative history of hypertension
| dc.contributor.author | Moodley, Yoshan | |
| dc.contributor.author | Biccard, Bruce M. | |
| dc.date.accessioned | 2015-04-21T12:47:10Z | |
| dc.date.available | 2015-04-21T12:47:10Z | |
| dc.date.issued | 2015-03-02 | |
| dc.description.abstract | Hypertension is an independent predictor of acute kidney injury (AKI) in non-cardiac surgery patients. There are a few published studies which report AKI following non-suprainguinal vascular procedures, but these studies have not investigated predictors of AKI, including anti-hypertensive medications and other comorbidities, in the hypertensive population alone. We sought to identify independent predictors of post-operative AKI in non-suprainguinal vascular surgery patients with a pre-operative history of hypertension. We performed univariate (chi-squared, or Fisher’s exact testing) and multivariate (binary logistic regression) statistical analysis of prospectively collected data from 243 adult hypertensive patients who underwent non-suprainguinal vascular surgery (lower limb amputation or peripheral artery bypass surgery) at a tertiary hospital between 2008 and 2011 in an attempt to identify possible associations between comorbidity, acute pre-operative antihypertensive medication administration, and post-operative AKI (a post-operative increase in serum creatinine of ≥ 25 % above the pre-operative measurement) in these patients. The incidence of post-operative AKI in this study was 5.3 % (95 % Confidence Interval: 3.2-8.9 %). Acute pre-operative β-blocker administration was independently associated with post-operative AKI in non-suprainguinal vascular surgery patients with a pre-operative history of hypertension (Odds Ratio: 3.24; 95 % Confidence Interval: 1.03-10.25). The acute pre-operative administration of β-blockers should be carefully considered in non-suprainguinal vascular surgery patients with a pre-operative history of hypertension, in lieu of an increased risk of potentially poor post-operative renal outcomes. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/34041 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-7271 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal ; Vol. 14, 2015 | en |
| dc.subject | Acute kidney injury | en |
| dc.subject | vascular surgery | en |
| dc.subject | hypertensive | en |
| dc.subject.ddc | 610 | |
| dc.title | Post-operative acute kidney injury in non-suprainguinal vascular surgery patients with a pre-operative history of hypertension | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 |