Wartungsarbeiten: Am 16.01.2025 von ca. 8:00 bis 11:00 Uhr steht Ihnen das System nicht zur Verfügung. Bitte stellen Sie sich entsprechend darauf ein.
 

DXS10079, DXS10074 and DXS10075

Simple item page
dc.contributor.authorAugustin, C.de
dc.contributor.authorDressler, J.de
dc.contributor.authorEdelmann, J.de
dc.contributor.authorHeidel, M.de
dc.contributor.authorHering, S.de
dc.contributor.authorRodig, H.de
dc.contributor.authorSzibor, R.de
dc.date.accessioned2008-06-17T14:13:24Z
dc.date.available2008-06-17T14:13:24Z
dc.date.issued2007-06-26de
dc.description.abstractThe number of established X-chromosomal STR markers suitable for forensic usage has risen continuously during recent years. The observation of X-chromosomal transmission lines can significantly contribute to the solving of complex kinship cases. The highly polymorphic tetranucleotide markers DXS10079, DXS10074 and DXS10075 are located within a 280 kb region at Xq12 and provide stable haplotypes. Most of these haplotypes occur at low frequencies in the German population, which would qualify this marker cluster as a useful tool in pedigree analysis. For routine use it is necessary to investigate the allele structure and check for variations in the repeat flanking region in samples of different ethnic populations. The information on SNP occurrence may help to minimise pitfalls caused by partial primer mismatching. We sequenced a variety of samples from Germans, Asians and Africans with respect to different STR alleles. For all three marker systems SNPs were detected in the repeat flanking regions. Some alleles found in the marker systems DXS10074 and DXS10075 exhibited typical repeat structures and SNP patterns found only in Africans and differing from Germans and Asians. The highest SNP diversity for DXS10079 was present in samples of all three ethnic groups. Further population data are needed to confirm this observation.en
dc.identifier.issn1611-2156de
dc.identifier.urihttp://hdl.handle.net/2003/25678
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-345
dc.language.isoende
dc.relation.ispartofseriesEXCLI Journal ; Vol. 6, 2007en
dc.subjectSNPen
dc.subjectSTR clusteren
dc.subjectX chromosomeen
dc.subjectXq12en
dc.subject.ddc610
dc.titleDXS10079, DXS10074 and DXS10075en
dc.title.alternativenew alleles and SNP occurrenceen
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Hering06-07proof.pdf
Size:
68.34 KB
Format:
Adobe Portable Document Format
Description:
DNB
Download

Collections

Original Articles