Epigenetics in diagnosis, prognostic assessment and treatment of cancer: an update

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dc.contributor.authorHatzimichael, Eleftheria
dc.contributor.authorLagos, Konstantinos
dc.contributor.authorSim, Van Ren
dc.contributor.authorBriasoulis, Evangelos
dc.contributor.authorCrook, Tim
dc.date.accessioned2014-11-27T13:00:10Z
dc.date.available2014-11-27T13:00:10Z
dc.date.issued2014-08-26
dc.description.abstractCancer cells contain multiple genetic and epigenetic changes. The relative specificity of many epigenetic changes for neoplastic cells has allowed the identification of diagnostic, prognostic and predictive biomarkers for a number of solid tumors and hematological malignancies. Moreover, epigenetically-acting drugs are already in routine use for cancer and numerous additional agents are in clinical trials. Here, we review recent progress in the development and application of epigenetic strategies for the diagnosis, risk stratification and treatment of cancer.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/33742
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-6936
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal ; Vol. 13, 2014en
dc.subjectepigeneticsen
dc.subjectmethylationen
dc.subjectacetylationen
dc.subjectdiagnosisen
dc.subjecttreatmenten
dc.subjectcanceren
dc.subjecthematological malignanciesen
dc.subjecthypomethylating agentsen
dc.subject.ddc610
dc.titleEpigenetics in diagnosis, prognostic assessment and treatment of cancer: an updateen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.deposittruede
eldorado.dnb.zdberstkatid2132560-1

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