Precondition of right frontal region with anodal tDCS can restore the fear memory impairment induced by ACPA in male mice

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dc.contributor.authorManteghi, Fariborz
dc.contributor.authorNasehi, Mohammad
dc.contributor.authorZarrindast, Mohammad-Reza
dc.date.accessioned2017-05-03T13:03:37Z
dc.date.available2017-05-03T13:03:37Z
dc.date.issued2017-01-02
dc.description.abstractFear memory and learning cause behavioural patterns such as fight or flight responses, which increase survival probability, but unfit processing of fear memory and learning can lead to maladaptive behaviours and maladies such as phobias, Post-Traumatic Stress Disorder (PTSD) and anxiety disorders. The growing prevalence of these maladies shows the need to quest novel methods for their treatment. We used anodal transcranial direct current stimulation (tDCS) on the right frontal region as a precondition neuromodulator and arachidonylcyclopropylamide (ACPA), a selective CB1 cannabinoid receptor agonist, as a fear memory impairing agent to assess their effects on contextual and auditory fear conditioning (reliable model for fear studies). Right frontal anodal tDCS (0.2 mA for. 20 minutes) 24 hours before the train did not alter contextual and auditory learning and memory in short-term (24 hrs after the training phase). Moreover, intraperitoneal pre-train injection of ACPA (0.1 mg/kg) alone, decreased both contextual and auditory learning and memory in short- but not long-term. Right frontal anodal tDCS improved short-term contextual fear memory in subthreshold doses of ACPA. On the other hand, right frontal anodal tDCS in long-term improved (lower doses of ACPA) and restored (higher doses of ACPA) both fear memories. These findings showed that, aforementioned approach could cause durable learning and memory improvements. Also this combined modality could be useful for fear extinction training and maladies which inflict amnesia.en
dc.identifier.doi10.17179/excli2016-693
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/35946
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-17969
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 16 2017en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjecttDCSen
dc.subjectACPAen
dc.subjectpreconditioningen
dc.subjectfear memoryen
dc.subjectme mory enhancementen
dc.subjectlearning accelerationen
dc.subject.ddc610
dc.titlePrecondition of right frontal region with anodal tDCS can restore the fear memory impairment induced by ACPA in male miceen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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