Anti-seizure activity of flower extracts of Nepeta bractaeta in Swiss albino mice

dc.contributor.authorAhmad, Mohd Aftab
dc.contributor.authorAnsari, Shahid
dc.contributor.authorAslam, Mohammad
dc.contributor.authorBhat, Jalal Uddin
dc.contributor.authorKhanam, Razia
dc.contributor.authorNizami, Qudsia
dc.contributor.authorParray, Shabir Ahmad
dc.contributor.authorSiddiqui, Aisha
dc.date.accessioned2012-11-16T10:12:38Z
dc.date.available2012-11-16T10:12:38Z
dc.date.issued2012-11-16
dc.description.abstractEpilepsy is a neurological disorder characterized by unprovoked, recurring seizures that disrupts the nervous system and can cause mental and physical dysfunction. Based on the ethno pharmacological information of the plant, the methanolic and aqueous extracts of the flowers of Nepeta bractaeta was evaluated for its antiepileptic activity. The methanolic and aqueous extracts of the flowers of Nepeta bracteata were observed for their antiepileptic activity by increased current Electroshock seizures (ICES) test and Pentylenetetrazole (PTZ) test using Swiss albino mice. Both the extracts showed significant activity in ICES and PTZ induced convulsions in comparison to control. In ICES model, NBAE at higher dose showed 16.7 % and NBME at higher dose showed 33.3 % protection against seizure and in PTZ model, NBME at higher dose showed 33.3 % protection against seizure. From the experiments performed, it can be said that Nepeta bractaeta does possess anticonvulsant property.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/29773
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-5136
dc.language.isoende
dc.relation.ispartofseriesEXCLI Journal ; Vol. 11, 2012en
dc.subjectantiepileptic effectsen
dc.subjectICESen
dc.subjectNepeta bractaetaen
dc.subjectPTZde
dc.subject.ddc610
dc.titleAnti-seizure activity of flower extracts of Nepeta bractaeta in Swiss albino miceen
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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