Interleukin-6 is associated with tryptophan metabolism and signs of depression in individuals with carbohydrate malabsorption

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dc.contributor.authorEnko, Dietmar
dc.contributor.authorZelzer, Sieglinde
dc.contributor.authorWenninger, Julian
dc.contributor.authorHolasek, Sandra
dc.contributor.authorSchnedl, Wolfgang J.
dc.contributor.authorBaranyi, Andreas
dc.contributor.authorHerrmann, Markus
dc.contributor.authorMeinitzer, Andreas
dc.date.accessioned2020-12-15T10:09:59Z
dc.date.available2020-12-15T10:09:59Z
dc.date.issued2020-10-28
dc.description.abstractThe aim of the present study was to investigate possible associations between interleukin-6 (IL-6), interferon-gamma (INF-γ), tumor necrosis factor-alpha (TNF-α), lactoferrin and lipopolysaccharide binding protein (LBP) with TRP metabolism and signs of depression in a large cohort of outpatients referred for carbohydrate malabsorption testing. Serum concentrations of IL-6, INF-γ, TNF-α, lactoferrin, LBP, tryptophan (TRP), kynurenine (KYN) and kynuric acid were determined in 250 adults referred for lactose and fructose malabsorption testing. All participants filled out the Beck Depression Inventory (BDI). Serum IL-6 levels were positively correlated with the BDI score (p = 0.001, ρ = 0.205) and indicators of TRP metabolism (KYN/TRP ratio, KYN) (P-values < 0.05, ρ = 0.176 and 0.136). Ninety-five individuals with a BDI score > 13 showed significantly higher IL-6 serum levels (1.7 [1.0 – 2.8] vs. 1.1 [0.8 – 1.7] pg/mL, p < 0.001) compared to 115 individuals with a BDI score ≤ 13. LBP showed a positive correlation with the KYN/TRP ratio (p = 0.005, ρ = 0.177). IL-6 and LBP were associated with indicators of TRP metabolism. IL-6 was found to be linked to signs of depression. Individuals with the presence of depressive symptoms showed higher serum IL-6 levels compared to individuals without depressive symptoms.en
dc.identifier.citationEnko, D., Zelzer, S., Wenninger, J., Holasek, S., Schnedl, W. J., Baranyi, A., Herrmann, M., & Meinitzer, A. (2020). Interleukin-6 is associated with tryptophan metabolism and signs of depression in individuals with carbohydrate malabsorption. EXCLI Journal, 19, 1414-1422. https://doi.org/10.17179/excli2020-2940en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/39899
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-21789
dc.language.isoen
dc.publisherIfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmunden
dc.relation.ispartofseriesEXCLI Journal;Vol. 19 2020
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDepressionen
dc.subjectInflammationen
dc.subjectInterleukin-6en
dc.subjectInterferon-gammaen
dc.subjectTumor necrosis factor-alphaen
dc.subjectLactoferrinen
dc.subject.ddc610
dc.titleInterleukin-6 is associated with tryptophan metabolism and signs of depression in individuals with carbohydrate malabsorptionen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.identifier.urlhttps://www.excli.de/index.php/excli/article/view/2940
eldorado.secondarypublicationtrue

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