Anti-inflammatory effects of isoketocharbroic acid from brown alga, Sargassum micracanthum

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dc.contributor.authorHam, Young Min
dc.contributor.authorYoon, Weon-Jong
dc.contributor.authorLee, Wook Jae
dc.contributor.authorKim, Sang-Cheol
dc.contributor.authorBaik, Jong Seok
dc.contributor.authorKim, Jin Hwa
dc.contributor.authorLee, Geun Soo
dc.contributor.authorLee, Nam Ho
dc.contributor.authorHyun, Chang-Gu
dc.date.accessioned2016-06-06T13:21:17Z
dc.date.available2016-06-06T13:21:17Z
dc.date.issued2015-10-15
dc.description.abstractDuring our on-going screening program designed to isolate natural compounds from marine environments, we isolated isoketochabrolic acid (IKCA) from Sargassum micracanthum, an important brown algae distributed in Jeju Island, Korea. Furthermore, we evaluated the inhibitory effects of IKCA on nitric oxide (NO) production in lipopolysaccharide (LPS)-triggered macrophages. IKCA strongly inhibited NO production, with an IC50 value of 58.31 μM. Subsequent studies demonstrated that IKCA potently and concentration-dependently reduced prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6 cytokine production. In conclusion, to the best of our knowledge, this is the first study to show that IKCA isolated from S. micracanthum has a potent anti-inflammatory activity. Therefore, IKCA might be useful as an anti-inflammatory health supplement or functional cosmetics.en
dc.identifier.doi10.17179/excli2015-555
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/35054
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-17102
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 14, 2015en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectbrown algaen
dc.subjectinflammationen
dc.subjectisoketochabrolic aciden
dc.subjectSargassum micracanthumen
dc.subject.ddc610
dc.titleAnti-inflammatory effects of isoketocharbroic acid from brown alga, Sargassum micracanthumen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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