Engineered TALE repeats for enhanced imaging-based analysisof cellular 5-Methylcytosine

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dc.contributor.authorMuñoz‐López, Alvaro
dc.contributor.authorJung, Anne
dc.contributor.authorBuchmuller, Benjamin
dc.contributor.authorWolffgramm, Jan
dc.contributor.authorMaurer, Sara
dc.contributor.authorWitte, Anna
dc.contributor.authorSummerer, Daniel
dc.date.accessioned2021-05-27T13:46:10Z
dc.date.available2021-05-27T13:46:10Z
dc.date.issued2020-09-20
dc.description.abstractTwo‐TALE test: Engineered transcription‐activator‐like effector (TALE) repeats can be used to design programmable receptors for improved in situ imaging‐based analysis of 5 mC in user‐defined DNA sequences. Pairs of natural 5 mC‐discriminating and engineered 5 mC‐binding TALEs allow nucleotide resolution analysis of 5 mC with response of both TALEs. This provides an impulse for the design of programmable imaging probes for studying 5 mC functions in chromatin regulation with increased dynamic range.en
dc.identifier.urihttp://hdl.handle.net/2003/40205
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-22078
dc.language.isoende
dc.relation.ispartofseriesChemBioChem;Vol. 22. 2021, Issue 4, pp 645-651
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDNA methylationen
dc.subjectEpigeneticsen
dc.subjectImaging probesen
dc.subjectMembrane-less organellesen
dc.subject.ddc570
dc.subject.ddc540
dc.titleEngineered TALE repeats for enhanced imaging-based analysisof cellular 5-Methylcytosineen
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access
eldorado.secondarypublicationtruede
eldorado.secondarypublication.primarycitationChemBioChem. Vol. 22. 2021, Issue 4, pp 645-651de
eldorado.secondarypublication.primaryidentifierhttps://doi.org/10.1002/cbic.202000563de

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