Effects of hesperidin on formaldehyde-induced toxicity in pregnant rats
| dc.contributor.author | Merzoug, Sameha | |
| dc.contributor.author | Toumi, Mohamed Lamine | |
| dc.date.accessioned | 2017-10-18T13:35:56Z | |
| dc.date.available | 2017-10-18T13:35:56Z | |
| dc.date.issued | 2017-03-30 | |
| dc.description.abstract | This experimental study aimed to investigate the protective effect of a bioflavonoid, hesperidin (HP), on formal- dehyde (FA)-related pathophysiological and behavioral outcomes in pregnant rats and developmental aspects in their offspring. Female Wistar rats were subjected to perigestational exposure to FA (2 mg/kg/day per os) with a concomitant treatment with HP (50 mg/kg/day per os). Pregnant rats were weighed throughout gestation and tested in two behavioral paradigms (elevated plus-maze and open field) at gestational days (GD) 1, 10 and 19 to evaluate the anxiety-like behavior and locomotive alterations. Another subset of rats was decapitated at GD19 to determine the hematological profile along with cortisol, 17β-estradiol, and progesterone plasma levels. Reproductive and fetal measures and observations were also performed to check for developmental deformities. Significant body weight loss, hemato-immune decline, hormonal changes, anxiety and lethargy signs, locomotor disabilities, repro- ductive failure and fetal weight decrease were observed in FA-exposed rats. Treatment with HP alleviated the reproductive and fetal weight defects. Its behavioral benefits were only seen at GD1 and 10. This flavanone ame- liorated some hematological parameters, decreased cortisol levels and increased 17β-estradiol rates. A potential preventive impact of HP was found against FA toxicity in pregnant rats. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/36126 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-18142 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal;Vol. 16 2017 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | formaldehyde | en |
| dc.subject | hesperidin | en |
| dc.subject | pathophysiology | en |
| dc.subject | behavior | en |
| dc.subject | gestation | en |
| dc.subject | fetal development | en |
| dc.subject.ddc | 610 | |
| dc.title | Effects of hesperidin on formaldehyde-induced toxicity in pregnant rats | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 | |
| eldorado.secondarypublication | true |