Increased serum IL-6 level time-dependently regulates hyperalgesia and spinal mu opioid receptor expression during CFA-induced arthritis
| dc.contributor.author | Alani, B. | |
| dc.contributor.author | Maghsoudi, N. | |
| dc.contributor.author | Manaheji, H. | |
| dc.contributor.author | Tekieh, E. | |
| dc.contributor.author | Zardooz, H. | |
| dc.contributor.author | Zaringhalam, J. | |
| dc.date.accessioned | 2011-05-17T12:50:08Z | |
| dc.date.available | 2011-05-17T12:50:08Z | |
| dc.date.issued | 2011-05-17 | |
| dc.description.abstract | Interleukin (IL)-6 is known to cause pro- and anti-inflammatory effects during different stages of inflammation. Recent therapeutic investigations have focused on treatment of various inflammatory disorders with anti-cytokine substances. As a result, the aim of this study was to further elucidate the influence of IL-6 in hyperalgesia and edema during different stages of Complete Freund’s Adjuvant (CFA)-induced arthritis (AA) in male Wistar rats. AA was induced by a single subcutaneous injection of CFA into the rats’ hindpaw. Anti-IL-6 was administered either daily or weekly during the 21 days of study. Spinal mu opioid receptor (mOR) expression was detected by Western blotting. Daily and weekly treatment with an anti-IL-6 antibody significantly decreased paw edema in the AA group compared to the AA control group. Additionally, daily and weekly anti-IL-6 administration significantly reduced hyperalgesia on day 7 in the AA group compared to the AA control group; however, there were significant increases in hyperalgesia in the antibody-treated group on days 14 and 21 compared to the AA control group. IL-6 antibody-induced increases in hyperalgesia on the 14th and 21st days after CFA injection correlated with a time-dependent, significant reduction in spinal mOR expression during anti-IL-6 treatment. Our study confirmed the important time-dependent relationship between serum IL-6 levels and hyperalgesia during AA. These results suggest that the stages of inflammation in AA must be considered for anti-hyperalgesic and anti-inflammatory interventions via anti-IL-6 antibody treatment. | en |
| dc.identifier.uri | http://hdl.handle.net/2003/27746 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-8841 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal ; Vol. 10, 2011 | en |
| dc.subject | arthritis | en |
| dc.subject | CFA | en |
| dc.subject | hyperalgesia | en |
| dc.subject | inflammation | en |
| dc.subject | interleukin-6 | en |
| dc.subject.ddc | 610 | |
| dc.title | Increased serum IL-6 level time-dependently regulates hyperalgesia and spinal mu opioid receptor expression during CFA-induced arthritis | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 |