Nitroxoline
| dc.contributor.author | Cherdtrakulkiat, Rungrot | |
| dc.contributor.author | Lawung, Ratana | |
| dc.contributor.author | Nabu, Sunanta | |
| dc.contributor.author | Tantimavanich, Srisurang | |
| dc.contributor.author | Sinthupoom, Nujarin | |
| dc.contributor.author | Prachayasittikul, Supaluk | |
| dc.contributor.author | Prachayasittikul, Virapong | |
| dc.date.accessioned | 2020-02-12T13:40:36Z | |
| dc.date.available | 2020-02-12T13:40:36Z | |
| dc.date.issued | 2019-06-26 | |
| dc.description.abstract | Antimicrobial resistance has become a prime global concern. An ability of the microbes to produce enzymes to destroy antimicrobial drugs is one of the well-known mechanisms underlying the resistance. 8-Hydroxyquinoline (8HQ) and derivatives were reported to exert diverse biological effects such as antimicrobial, antioxidant and an- tineurodegenerative activities. Herein, 8HQ (1), nitroxoline (NQ, 2) and 7-Br-8HQ (3) were investigated for antimicrobial activity against Enterobacteriaceae including extended spectrum β-lactamase (ESBL)-producing and carbapenemase-producing strains as well as the effect of metal ions .These compounds (1-3) displayed the great antimicrobial activity against fifty-eight bacterial isolates of Escherichia coli, Providencia rettgeri and Klebsiella pneumoniae, in which NQ (2) exerted the highest antimicrobial activity with a MIC50 of 42.04 ❍M (8 µg/mL) and MBC50 of 168.28 ❍M (32 µg/mL). The MIC values of NQ (2) and 7-Br-8HQ (3) were significantly increased in the presence of Cu2+ and Fe3+. This finding reveals that NQ could be an effective compound to be further developed as an antimicrobial agent for combating Enterobacteriaceae infections. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/38567 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-20486 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal;Vol. 18. 2019 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Enterobacteriaceae | en |
| dc.subject | Multidrug resistance | en |
| dc.subject | Antimicrobial activity | en |
| dc.subject | 8-hydroxyquinoline | en |
| dc.subject | Nitroxoline | en |
| dc.subject.ddc | 610 | |
| dc.title | Nitroxoline | en |
| dc.title.alternative | a potent antimicrobial agent against multidrug resistant Enterobacteriaceae | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 | |
| eldorado.secondarypublication | true |
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