Androgen receptor (AR)-CAG trinucleotide repeat length and idiopathic male infertility

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dc.contributor.authorMobasseri, Narges
dc.contributor.authorBabaei, Faezeh
dc.contributor.authorKarimian, Mohammad
dc.contributor.authorNikzad, Hossein
dc.date.accessioned2019-04-05T07:43:44Z
dc.date.available2019-04-05T07:43:44Z
dc.date.issued2018-12-17
dc.description.abstractCAG trinucleotide repeats in androgen receptor (AR) gene encode a polyglutamine tract in AR N-terminal transactivation domain. Studies have been conducted to evaluate the effect of CAG repeat length on male infertility, which have yielded contradictory results. This study aimed to explore the number of AR-CAG repeats in 150 fertile controls and 150 idiopathic infertile men, divided into four azoospermia, oligozoospermia, asthenozoospermia, and teratozoospermia subgroups. In addition, a meta-analysis was conducted based on previous studies to assess the association of the mentioned variation with male infertility in recent years. Polymerase chain reaction (PCR) targeting followed by an electrophoresis on polyacrylamide gel was used for AR-CAG genotype detecting. Moreover, a systematic search was performed in PubMed, Web of Science, Science Direct, and Google Scholar databases to collect eligible studies for meta-analysis purpose. According to the results, a significant association was observed between increased length of AR-CAG polymorphism and male infertility (p< 0.0001). Furthermore, there were similar significant associations in the azoospermia (p= 0.048), asthenozoospermia (p= 0.013) and teratozoospermia (p= 0.002) subgroups. In addition, meta-analysis on forty studies showed a significant association between AR-CAG polymorphism in the overall analysis (SMD= 0.199, 95 % CI= 0.112-0.287, p<0.001) and the Caucasian subgroup (SMD= 0.151, 95 % CI= 0.040-0.263, p= 0.008). Our results elucidated that long stretches of CAG repeat might lead to AR dysfunction, contributing to male infertility especially in the Caucasian population.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/37983
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-19967
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 17 2018
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMale infertilityen
dc.subjectAndrogen receptoren
dc.subjectCAG repeaten
dc.subjectGenetic associationen
dc.subject.ddc610
dc.titleAndrogen receptor (AR)-CAG trinucleotide repeat length and idiopathic male infertilityen
dc.title.alternativea case-control trial and a meta-analysisen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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