Association between the CD40 rs1883832 polymorphism and Graves' disease risk
| dc.contributor.author | Wang, Xiao-Xiong | |
| dc.contributor.author | Wang, Xiao-Xia | |
| dc.contributor.author | Chen, Tong | |
| dc.date.accessioned | 2019-05-20T11:18:53Z | |
| dc.date.available | 2019-05-20T11:18:53Z | |
| dc.date.issued | 2019-01-23 | |
| dc.description.abstract | This meta-analysis aims to evaluate whether the CD40 rs1883832 polymorphism is associated with Graves’ disease (GD) risk in different populations. We performed a systematic literature search in China National Knowledge Infrastructure (CNKI), Web of Science, and Pubmed databases to identify case-control association studies on the association between rs1883832 and GD risk. For each study we calculated the odds ratios (OR) and 95 % confidence intervals (CI) assuming dominant, recessive and homozygote models. We then calculated pooled ORs and 95 % CIs. After applying inclusion and exclusion criteria, 17 studies involving 4707 cases and 4215 controls were included in the meta-analysis. The results showed that rs1883832 was associated with GD risk in Asians under dominant (CT + TT vs CC, OR=0.67, 95 % CI: 0.56-0.81, P<0.001), recessive (TT vs CT + CC, OR=0.58, 95 % CI: 0.47-0.72, P<0.001), and homozygote (TT vs CC, OR=0.49, 95 % CI: 0.37-0.64, P<0.001) models. In Caucasians, rs1883832 was associated with GD risk under the dominant model (CT + TT vs CC, OR=0.82, 95 % CI: 0.68-0.99, P=0.042). Besides GD, we evaluated the relation of rs1883832 with Graves’ ophthalmopathy (GO), finding that rs1883832 was associated with GO under the dominant model (CT + TT vs CC, OR=0.82, 95 % CI: 0.69-0.98, P=0.031). The findings of our meta-analysis suggest that the CD40 rs1883832 polymorphism is protective against GD and GO in Asians and Caucasians. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/38055 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-20038 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal;Vol. 18 2019 | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | CD40 | en |
| dc.subject | Graves’ disease | en |
| dc.subject | Meta-analysis | en |
| dc.subject | Polymorphism | en |
| dc.subject.ddc | 610 | |
| dc.title | Association between the CD40 rs1883832 polymorphism and Graves' disease risk | en |
| dc.title.alternative | a meta-analysis | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 | |
| eldorado.secondarypublication | true |