Antioxidant and nephro-protective effect of Juglans regia vegetable oil against lead-induced nephrotoxicity in rats and its characterization by GC-MS
Loading...
Date
2018-05-23
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Lead (Pb) intoxication remains a major health hazard causing various deleterious effects especially on renal and
hematologic system. The current study elucidated the potential protective effect of JRVO against nephrotoxicity
induced by lead. Male rats were randomly divided into three groups: group one (control) received ad libitum
distilled water and 1 mL of saline solution (0.9 %) given by intra-peritoneal (i.p) injection, group two (Pb) was
kept on tap distilled water and animals were i.p, injected daily with lead every two days from day five until day
ten, namely the sacrifice day, and group three (Pb+J) was administered by intra-peritoneal injection of Pb with the
same dose and same way with Group two, while JRVO extract was administered daily by gavage during ten days.
The exposure of lead reduced the number of red and white blood cells. Besides, plasma biomarkers (urea, uric
acid, creatinine, LDH and ALP) levels were reduced. Lipid and protein per-oxidations increased and objectified
by high TBARS and PCOs levels, while glutathione peroxidase, superoxide dismutase and catalase activities
showed a significant decline after ten-day treatment. Conversely, the JRVO prevented kidney biomarker changes
by improving hepatotoxicity induced by lead as evidenced by restoring the biochemical markers cited above to
near normal levels. Kidney histoarchitecture confirmed the biochemical parameters and the beneficial role of
JRVO. It can be concluded that the administration of JRVO alleviates Pb-induced toxicity, thus demonstrating its
potent antioxidant efficacy.
Description
Table of contents
Keywords
Antioxidant activities, GC-MS, Juglans regia, Nephrotoxicity, Lead, Rats