Serum vitamin D levels in patients with chronic kidney disease
| dc.contributor.author | Rozita, Mohd | |
| dc.contributor.author | Noorul Afidza, Mohamad | |
| dc.contributor.author | Ruslinda, Mustafar | |
| dc.contributor.author | Cader, Rizna | |
| dc.contributor.author | Halim, A. Gafor | |
| dc.contributor.author | Kong, Chiew Tong Norella | |
| dc.contributor.author | Nor Azm, Kamaruddin | |
| dc.contributor.author | Shah, Shamsul Azhar | |
| dc.date.accessioned | 2014-03-10T10:42:11Z | |
| dc.date.available | 2014-03-10T10:42:11Z | |
| dc.date.issued | 2013-06-11 | |
| dc.description.abstract | Introduction: Hypovitaminosis D is reported to be associated with several medical complications. Recent studies have reported a high worldwide prevalence of Vitamin D deficiency in the general population (up to 80 %). This is even higher in patients with chronic kidney disease (CKD) and increases with advancing stages of CKD. Objectives: To determine the difference in serum Vitamin D [25-hydroxyvitamin D, 25(OH) D] levels between CKD patients and normal healthy population. Materials and Methods: A prospective crosssectional study involving 50 normal volunteers (control) and 50 patients with CKD stages 2-4. Their demographic profiles were recorded and blood samples taken for serum 25(OH) D, intact parathyroid hormone (iPTH) and other routine blood tests. Results: All subjects regardless of renal status had hypovitaminosis D (< 30ng/mL). The mean serum 25(OH) D were comparable in the control and CKD groups (15.3 ± 4.2 ng/mL vs 16.1 ± 6.2 ng/mL, p = NS). However, within the Vitamin D deficient group, the CKD group had lower levels of serum 25(OH) D [12.6( 3.7) ng/mL vs 11.2(6.5) ng/mL, p = 0.039]. Female gender [OR 22.553; CI 95 % (2.16-235.48); p = 0.009] and diabetic status [OR 6.456; CI 95 % (1.144-36.433); p = 0.035] were independent predictors for 25(OH) D deficiency. Conclusions: Vitamin D insufficiency and vitamin D deficiency are indeed prevalent and under-recognized. Although the vitamin D levels among the study subjects and their control are equally low, the CKD group had severe degree of vitamin D deficiency. Diabetic status and female gender were independent predictors of low serum 25(OH)D. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/32941 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-7481 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal ; Vol. 12, 2013 | en |
| dc.subject | 25-hydroxyvitamin D | en |
| dc.subject | vitamin D insufficiency and deficiency | en |
| dc.subject | normal population | en |
| dc.subject | CKD patients | en |
| dc.subject.ddc | 610 | |
| dc.title | Serum vitamin D levels in patients with chronic kidney disease | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 |