Beyond the joints in rheumatoid arthritis
| dc.contributor.author | Hussein, H. | |
| dc.contributor.author | Mohd Shahrir, M.S. | |
| dc.contributor.author | Sakthiswary, R. | |
| dc.contributor.author | Shahril, N.S. | |
| dc.contributor.author | Syahrul Sazliyana, S. | |
| dc.date.accessioned | 2012-10-11T12:40:28Z | |
| dc.date.available | 2012-10-11T12:40:28Z | |
| dc.date.issued | 2012-10-11 | |
| dc.description.abstract | Introduction: Tumor necrosis factor alpha (TNFα) is a multifunctional cytokine which plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA). Apart from its well recognized pro-inflammatory properties, it is known to interfere with lipid metabolism and erythropoiesis. Materials and Methods: We evaluated the effects of adalimumab on hematologic, lipid and inflammatory parameters using data from patients on adalimumab 40 mg fortnightly from 2 centers in Malaysia. Mean changes in laboratory values from baseline to Weeks 4, 12 and 24 were compared using paired T test and Wilcoxon signed-rank test. Results: We studied 18 patients with RA who were on adalimumab 40 mg fortnightly. The inflammatory markers i.e. erythrocyte sedimentation rate and C reactive protein showed significant changes as early as at week 4 compared to baseline with p values of 0.003 and 0.005, respectively. From a baseline of high disease activity with a mean Disease Activity Score using 28 joint counts (DAS 28) of 5.3, there was a steady improvement in the disease activity and remission was achieved at week 24 with a DAS 28 of 2.4. The hemoglobin level improved at week 12 (p=0.013) and this was sustained till week 24. As opposed to previous studies, the LDL level significantly decreased at week 12 (p=0.015) and this change persisted till week 24 (p=0.001). The total cholesterol showed a similar pattern as the LDL. Conclusions: The pharmacodynamics of adalimumab therapy in rheumatoid arthritis extend beyond the joints with favorable effects on haemoglobin and lipid profile. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/29667 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-5609 | |
| dc.language.iso | en | de |
| dc.relation.ispartofseries | EXCLI Journal ; Vol. 11, 2012 | en |
| dc.subject | adalimumab | en |
| dc.subject | anemia | en |
| dc.subject | lipid profile | en |
| dc.subject | rheumatoid arthritis | en |
| dc.subject.ddc | 610 | |
| dc.title | Beyond the joints in rheumatoid arthritis | en |
| dc.title.alternative | effects of adalimumab on hematologic and lipid indices | en |
| dc.type | Text | de |
| dc.type.publicationtype | article | de |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 |