The erratic antibiotic susceptibility patterns of bacterial pathogens causing urinary tract infections

dc.contributor.authorAhmed, Iftkhar
dc.contributor.authorSajed, Muhammad
dc.contributor.authorSultan, Aneesa
dc.contributor.authorMurtaza, Iram
dc.contributor.authorYousaf, Sohail
dc.contributor.authorMaqsood, Bushra
dc.contributor.authorVanhara, Petr
dc.contributor.authorAnees, Mariam
dc.date.accessioned2016-06-06T10:33:53Z
dc.date.available2016-06-06T10:33:53Z
dc.date.issued2015-08-04
dc.description.abstractIncreasing trend of antibiotic resistance and expression of Extended Spectrum Beta Lactamases (ESBLs) are serious threats for public health as they render the treatment ineffective. Present study was designed to elucidate the antibiotic-susceptibility patterns of ESBL and non-ESBL producing E. coli and K. pneumoniae causing urinary tract infections so that the ineffective antibiotics could be removed from the line of treatment. The bacterial isolates obtained from the urine of patients visiting a tertiary health care facility were cultured for strain identification using API20E. Antimicrobial susceptibility and ESBL detection were done by Kirby-bauer diffusion technique. Almost 53.4 % isolates of E. coli and 24.5 % isolates of K. pneumoniae were found to be ESBL producers. The ESBL producing bacteria were found to be more resistant towards various antibiotics. The most effective drugs against E. coli ESBL isolates were imipenem (99.54 %), ampicillin-sulbactam (97.48 %), piperacillin-tazobactam (96.86 %), fosfomycin (94.51 %), amikacin (92.26 %) and nitrofurantoin (90.68 %). The most effective drugs against K. pneumoniae ESBL isolates were imipenem (97.62 %), piperacillin-tazobactam (95.35 %), ampicillin-sulbactam (90.48 %) and amikacin (88.37 %). The antibiotics having the highest resistance, particularly by the ESBL producers were amoxicillin clavulanic acid, sulphamethoxalzole/ trimethoprim, cefuroxime, cefpirome, ceftriaxone and ciprofloxacin. Most of the isolates showed multi drug resistance (MDR). High frequency of ESBL producing E. coli and K. pneumoniae were observed as compared to previous data. Penicillins, cephalosporins and some representatives of fluoroquinolones were least effective against the common UTIs and are recommended to be removed from the line of treatment.en
dc.identifier.doi10.17179/excli2015-207
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/35037
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-17085
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 14, 2015en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEscherichia colien
dc.subjectKlebsiella pneumoniaeen
dc.subjectESBLen
dc.subjectantibiotic susceptibilityen
dc.subject.ddc610
dc.titleThe erratic antibiotic susceptibility patterns of bacterial pathogens causing urinary tract infectionsen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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