Hepatotoxicity induced by zoledronic acid in an aged woman with primary osteoporosis

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dc.contributor.authorFang, Fusheng
dc.contributor.authorJin, Mengmeng
dc.contributor.authorLi, Chunlin
dc.contributor.authorLi, Jian
dc.contributor.authorLiu, Minyan
dc.contributor.authorLu, Yanhui
dc.contributor.authorMa, Lichao
dc.contributor.authorPei, Yu
dc.contributor.authorShao, Yinghong
dc.contributor.authorYan, Shuangtong
dc.date.accessioned2013-05-22T09:37:02Z
dc.date.available2013-05-22T09:37:02Z
dc.date.issued2013-05-22
dc.description.abstractZoledronic acid, a bisphosphonate, has been approved for treatment and prevention of osteoporosis. This case describes a 73-year-old woman with primary osteoporosis who developed transient hepatotoxicity after zoledronic acid (ZOL) treatment. Three days after ZOL infusion, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyltransferase (GGT) were increased by 9.9, 8.1, and 3.7 times, respectively, compared with pretreatment values. Liver protective agents were administered. The aminotransferase returned within normal ranges 12 days post-infusion. Currently, the relationship of ZOL and liver damage is not quite clear, which cannot be explained by its pharmacokinetics. The aim of this case report is to increase the clinician’s awareness of the possible adverse effect on the liver, and ZOL should be cautiously administered in patients with liver disease.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/30335
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-5508
dc.language.isoende
dc.relation.ispartofseriesEXCLI Journal ; Vol. 12, 2013en
dc.subjectbisphosphonatesen
dc.subjecthepatotoxicityen
dc.subjectosteoporosisen
dc.subject.ddc610
dc.titleHepatotoxicity induced by zoledronic acid in an aged woman with primary osteoporosisen
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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