Aluminium oxide nanoparticles compromise spatial learning and memory performance in rats

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dc.contributor.authorM’rad, Imen
dc.contributor.authorJeljeli, Mustapha
dc.contributor.authorRihane, Naima
dc.contributor.authorHilber, Pascal
dc.contributor.authorSakly, Mohsen
dc.contributor.authorAmara, Salem
dc.date.accessioned2018-06-15T09:07:56Z
dc.date.available2018-06-15T09:07:56Z
dc.date.issued2018-02-14
dc.description.abstractRecently, the biosafety and potential influences of nanoparticles on central nervous system have received more attention. In the present study, we assessed the effect of aluminium oxide nanoparticles (Al2O3-NPs) on spatial cognition. Male Wistar rats were intravenously administered Al2O3-NP suspension (20 mg/kg body weight/day) for four consecutive days, after which they were assessed. The results indicated that Al2O3-NPs impaired spatial learning and memory ability. An increment in malondialdehyde levels with a concomitant decrease in superoxide dismutase activity confirmed the induction of oxidative stress in the hippocampus. Additionally, our findings showed that exposure to Al2O3-NPs resulted in decreased acetylcholinesterase activity in the hippocampus. Fur- thermore, Al2O3-NPs enhanced aluminium (Al) accumulation and disrupted mineral element homoeostasis in the hippocampus. However, they did not change the morphology of the hippocampus. Our results show a connection among oxidative stress, disruption of mineral element homoeostasis, and Al accumulation in the hippocampus, which leads to spatial memory deficit in rats treated with Al2O3-NPs.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/36917
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-18916
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 17 2018
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAluminium oxide nanoparticleen
dc.subjectHippocampusen
dc.subjectOxidative responseen
dc.subjectSpatial memoryen
dc.subject.ddc610
dc.titleAluminium oxide nanoparticles compromise spatial learning and memory performance in ratsen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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