Aluminium oxide nanoparticles compromise spatial learning and memory performance in rats
dc.contributor.author | M’rad, Imen | |
dc.contributor.author | Jeljeli, Mustapha | |
dc.contributor.author | Rihane, Naima | |
dc.contributor.author | Hilber, Pascal | |
dc.contributor.author | Sakly, Mohsen | |
dc.contributor.author | Amara, Salem | |
dc.date.accessioned | 2018-06-15T09:07:56Z | |
dc.date.available | 2018-06-15T09:07:56Z | |
dc.date.issued | 2018-02-14 | |
dc.description.abstract | Recently, the biosafety and potential influences of nanoparticles on central nervous system have received more attention. In the present study, we assessed the effect of aluminium oxide nanoparticles (Al2O3-NPs) on spatial cognition. Male Wistar rats were intravenously administered Al2O3-NP suspension (20 mg/kg body weight/day) for four consecutive days, after which they were assessed. The results indicated that Al2O3-NPs impaired spatial learning and memory ability. An increment in malondialdehyde levels with a concomitant decrease in superoxide dismutase activity confirmed the induction of oxidative stress in the hippocampus. Additionally, our findings showed that exposure to Al2O3-NPs resulted in decreased acetylcholinesterase activity in the hippocampus. Fur- thermore, Al2O3-NPs enhanced aluminium (Al) accumulation and disrupted mineral element homoeostasis in the hippocampus. However, they did not change the morphology of the hippocampus. Our results show a connection among oxidative stress, disruption of mineral element homoeostasis, and Al accumulation in the hippocampus, which leads to spatial memory deficit in rats treated with Al2O3-NPs. | en |
dc.identifier.issn | 1611-2156 | |
dc.identifier.uri | http://hdl.handle.net/2003/36917 | |
dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-18916 | |
dc.language.iso | en | |
dc.relation.ispartofseries | EXCLI Journal;Vol. 17 2018 | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Aluminium oxide nanoparticle | en |
dc.subject | Hippocampus | en |
dc.subject | Oxidative response | en |
dc.subject | Spatial memory | en |
dc.subject.ddc | 610 | |
dc.title | Aluminium oxide nanoparticles compromise spatial learning and memory performance in rats | en |
dc.type | Text | |
dc.type.publicationtype | article | |
dcterms.accessRights | open access | |
eldorado.dnb.zdberstkatid | 2132560-1 | |
eldorado.secondarypublication | true |
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