Immunology of IL-12
| dc.contributor.author | Ullrich, Karen Anne-Marie | |
| dc.contributor.author | Schulze, Lisa Lou | |
| dc.contributor.author | Paap, Eva-Maria | |
| dc.contributor.author | Müller, Tanja Martina | |
| dc.contributor.author | Neurath, Markus F. | |
| dc.contributor.author | Zundler, Sebastian | |
| dc.date.accessioned | 2020-12-17T14:16:46Z | |
| dc.date.available | 2020-12-17T14:16:46Z | |
| dc.date.issued | 2020-12-11 | |
| dc.description.abstract | As its first identified member, Interleukin-12 (IL-12) named a whole family of cytokines. In response to pathogens, the heterodimeric protein, consisting of the two subunits p35 and p40, is secreted by phagocytic cells. Binding of IL-12 to the IL-12 receptor (IL-12R) on T and natural killer (NK) cells leads to signaling via signal transducer and activator of transcription 4 (STAT4) and subsequent interferon gamma (IFN-γ) production and secretion. Signaling downstream of IFN-γ includes activation of T-box transcription factor TBX21 (Tbet) and induces pro-inflammatory functions of T helper 1 (TH1) cells, thereby linking innate and adaptive immune responses. Initial views on the role of IL-12 and clinical efforts to translate them into therapeutic approaches had to be re-interpreted following the discovery of other members of the IL-12 family, such as IL-23, sharing a subunit with IL-12. However, the importance of IL-12 with regard to immune processes in the context of infection and (auto-) inflammation is still beyond doubt. In this review, we will provide an update on functional activities of IL-12 and their implications for disease. We will begin with a summary on structure and function of the cytokine itself as well as its receptor and outline the signal transduction and the transcriptional regulation of IL-12 secretion. In the second part of the review, we will depict the involvement of IL-12 in immune-mediated diseases and relevant experimental disease models, while also providing an outlook on potential translational approaches. | en |
| dc.identifier.citation | Ullrich, K. A.-M., Schulze, L. L., Paap, E.-M., Müller, T. M., Neurath, M. F., & Zundler, S. (2020). Review article - Immunology of IL-12: An update on functional activities and implications for disease. EXCLI Journal, 19, 1563-1589. https://doi.org/10.17179/excli2020-3104 | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/39921 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-21811 | |
| dc.language.iso | en | |
| dc.publisher | IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund | en |
| dc.relation.ispartofseries | EXCLI Journal;Vol. 19 2020 | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | IL-12 | en |
| dc.subject | TH1 cells | en |
| dc.subject | STAT4 | en |
| dc.subject | Immunology | en |
| dc.subject | Cytokines | en |
| dc.subject | ustekinumab | en |
| dc.subject.ddc | 610 | |
| dc.title | Immunology of IL-12 | en |
| dc.title.alternative | an update on functional activities and implications for disease | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 | |
| eldorado.dnb.zdberstkatid | true | |
| eldorado.identifier.url | https://www.excli.de/index.php/excli/article/view/3104 |