The role of a2ß1 integrin in anchorage dependent apoptosis of breast carcinoma and hepatoma cells

dc.contributor.author	Berman, A. E.	de
dc.contributor.author	Kozlova, N. I.	de
dc.contributor.author	Morozevich, G. E.	de
dc.contributor.author	Preobrazhenskaya, M. E.	de
dc.contributor.author	Shtil, A. A.	de
dc.contributor.author	Ushakova, N. A.	de
dc.date.accessioned	2008-06-17T14:14:42Z
dc.date.available	2008-06-17T14:14:42Z
dc.date.issued	2007-05-31	de
dc.description.abstract	The role of collagen specific a2ß1 integrin in anchorage dependent apoptosis (anoikis) was investigated. Stimulation of a2ß1 signaling with immobilized anti-a2 antibody markedly sensitized human MCF-7 breast carcinoma and HepG2 hepatoma cells to anoikis. Accordingly, down-regulation of a2ß1 by a2-specific siRNA decreased the percentage of cells undergoing anoikis. These results for the first time provide direct evidence that a2ß1 receptor can transduce the signal to promote death in matrix deprived cells.	en
dc.identifier.issn	1611-2156	de
dc.identifier.uri	http://hdl.handle.net/2003/25684
dc.identifier.uri	http://dx.doi.org/10.17877/DE290R-8188
dc.language.iso	en	de
dc.relation.ispartofseries	EXCLI Journal ; Vol. 6, 2007	en
dc.subject	anoikis	en
dc.subject	apoptosis	en
dc.subject	extracellular matrix	en
dc.subject	integrins	en
dc.subject	signaling	en
dc.subject.ddc	610
dc.title	The role of a2ß1 integrin in anchorage dependent apoptosis of breast carcinoma and hepatoma cells	en
dc.type	Text	de
dc.type.publicationtype	article	de
dcterms.accessRights	open access
eldorado.dnb.zdberstkatid	2132560-1

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