Using curcumin to prevent structural impairments of testicles in rats induced by sodium metabisulfite
| dc.contributor.author | Mahmoudi, Reza | |
| dc.contributor.author | Honarmand, Zahra | |
| dc.contributor.author | Karbalay-Doust, Saied | |
| dc.contributor.author | Jafari-Barmak, Mehrzad | |
| dc.contributor.author | Nikseresht, Mohsen | |
| dc.contributor.author | Noorafshan, Ali | |
| dc.date.accessioned | 2017-10-26T13:07:57Z | |
| dc.date.available | 2017-10-26T13:07:57Z | |
| dc.date.issued | 2017-04-24 | |
| dc.description.abstract | Sodium metabisulfite (Na-MBS) is a disinfectant and preservative agent. Some organ including testicle would be in danger in the case of Na-MBS consumption. Curcumin (CUR) is the constituent of turmeric with protective properties. The effect of CUR on testicles in rats exposed to Na-MBS evaluated using stereological methods. Sprague-Dawley rats were divided into eight groups. The rats in groups I to VIII received the following respec- tively: distilled water, CUR (100 mg/kg/day), low (0.7 mg/kg/day: acceptable daily intake), intermediate (7 mg/ kg/day), and high (70 mg/kg/day) doses of Na-MBS, and low, intermediate, and high doses of Na-MBS plus CUR. After 7 weeks, the testicles were analyzed. The volume of seminiferous tubule, tubular epithelium and tubule length reduced (25-40 %) on average in the rats that received intermediate and high doses of Na-MBS, while the connective tissue volume increased (15-20 %) in both groups (P<0.01). Besides, 19-36 % and 41-57 % of the cells (spermatogonia types A and B, spermatids, Sertoli and Leydig) were lost in the rats that received intermediate and high doses of Na-MBS respectively in comparison to the control groups. Nonetheless, all the above-mentioned alterations ameliorated drastically in the rats that received Na-MBS plus CUR compared to those exposed to Na- MBS without CUR therapy (P<0.01). The acceptable daily intake of Na-MBS for 7 weeks did not affect on testic- ular parameters. CUR (100 mg/kg/day) could prevent structural impairments of testicles in the rats induced by Na-MBS (7 and 70 mg/kg/day). | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/36150 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-18166 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal;Vol. 16 2017 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | curcumin | en |
| dc.subject | rat | en |
| dc.subject | sodium metabisulfite | en |
| dc.subject | stereology | en |
| dc.subject | testicle | en |
| dc.subject.ddc | 610 | |
| dc.title | Using curcumin to prevent structural impairments of testicles in rats induced by sodium metabisulfite | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 | |
| eldorado.secondarypublication | true |