Serum protein electrophoresis under effective control of HIV-1 disease progression

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dc.contributor.authorAdedeji, Adebayo Lawrence
dc.contributor.authorAdenikinju, Rufus Omotayo
dc.contributor.authorAjele, Joshua Olufemi
dc.contributor.authorOlawoye, Theophilus Ladapo
dc.date.accessioned2014-11-25T13:16:36Z
dc.date.available2014-11-25T13:16:36Z
dc.date.issued2014-07-15
dc.description.abstractIn this report, we compared the serum protein electrophoresis (SPE) patterns in a subset of HIV-1-infected subjects who did not progress to AIDS without antiretroviral treatment with those in whose control of disease progression was achieved by highly active antiretroviral therapy (HAART). SPE and immunofixation electrophoresis were performed on Helena Electrophoresis System according to manufacturer’s instructions. The percentage of SPE abnormalities, resembling chronic inflammation, was significantly higher in HIV-1-infected subject without HAART compared with those under HAART (p = 0.001). The majority of individuals under HAART showed evidence of oligoclonal bands on the γ-band against a polyclonal background compared with those without HAART but β-γ-band bridging was more evident. Immunofixation pattern was consistent with oligoclonal hypergammaglobulinaemia of IgG kappa type, which was found to be more intense in group without HAART. HIV clinical status did not show appreciable effect on the SPE pattern in subjects without HAART. However, under effective HAART, subjects with better CD4 T-cell count were associated with higher γ-globulin band. In group without HAART, acute infection was found to be associated the higher γ-globulin fraction compared with chronic infection. The opposite was the case under effective HAART. HIV infected subjects that did not progress to AIDS were associated with markedly abnormal SPE pattern. Overall results reflect the host ability compensate defective cellular immunity in HIV-1 infection with humoral immune responses. These findings underscore the usefulness of SPE monitoring HIV disease management and identifying individuals that may not progress to full-blown AIDS in the absence of treatment.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/33709
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-6926
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal ; Vol. 13, 2014en
dc.subjectHIVen
dc.subjectHAARTen
dc.subjectSPEen
dc.subjectIFEen
dc.subjectclinical statusen
dc.subjectdurationen
dc.subject.ddc610
dc.titleSerum protein electrophoresis under effective control of HIV-1 disease progressionen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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