Beta-(1-adamantylthio)pyridine analogs as antimicrobials and antimalarials

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dc.contributor.authorLimnusont, Phattrapoom
dc.contributor.authorPingaew, Ratchanok
dc.contributor.authorPrachayasittikul, Supaluk
dc.contributor.authorPrachayasittikul, Virapong
dc.contributor.authorRuchirawat, Somsak
dc.date.accessioned2009-03-11T10:24:01Z
dc.date.available2009-03-11T10:24:01Z
dc.date.issued2009-03-11T10:24:01Z
dc.description.abstractAn array of interesting activities for bioactive 3-substituted thiopyridines have previously been reported. Herein, a series of α- and β-(1-adamantylthio) analogs of 3-picoline and phenylpyridines were prepared and investigated for antimicrobial (agar dilution method against 21 strains of microorganisms) and antimalarial (against P. falciparum) activities. It was found that β-thiopyridines, 5-(1-adamantylthio)-3-picoline (7) and 3-(1-adamantylthio)-4-phenylpyridine (8) are novel antimicrobials and antimalarials. Significantly, analogs 7 and 8 are very potent antimicrobials with MIC range of 2-32 µg/mL where 8 being the most potent. The β-sulfides 7 and 8 selectively inhibited the growth of tested gram-positive bacteria, but inactive against gram-negative bacilli including the members of Enterobacteriaceae. This study identified new antimicrobials that represent promising lead compounds suitable for fur-ther preclinical and clinical development.en
dc.identifier.urihttp://hdl.handle.net/2003/26038
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-14331
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal ; Vol. 8, 2009en
dc.subject1-adamantylthioen
dc.subject3-picolineen
dc.subjectantimalarialsen
dc.subjectantimicrobialsen
dc.subjectphenylpyridinesen
dc.subject.ddc610
dc.titleBeta-(1-adamantylthio)pyridine analogs as antimicrobials and antimalarialsen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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