Contralateral cortical role on functional recovery in a rat model of hemiplegia

dc.contributor.authorIkeda, Satoshi
dc.contributor.authorHarada, Katsuhiro
dc.contributor.authorOhwatashi, Akihiko
dc.contributor.authorKamikawa, Yurie
dc.contributor.authorYoshida, Akira
dc.date.accessioned2014-03-10T13:35:17Z
dc.date.available2014-03-10T13:35:17Z
dc.date.issued2013-07-17
dc.description.abstractThe role of the contralateral cerebral cortical plasticity in functional recovery after cerebral infarction is controversial. To clarify this role, we made a second contralateral cortical infarction after recovery from the first cerebral infarction. To produce the first infarction, Wistar rats were intravenously injected with Rose Bengal to the sensorimotor area of the right hemisphere of the cerebral cortex under green-light irradiation. Two weeks after the first hemiplegia, a secondary infarction was induced in the left cerebral cortex. Functional recovery was evaluated in a beam-walking test. Hemiplegia observed 1 day after both the first and second infarctions was given a score of 1. At 14 days after the first infarction, the average recovery score (± standard error) was 6.8 ± 0.1. In contrast, functional recovery was slower after the second infarction, reaching an average score of only 3.5 ± 0.5 after 14 days. Therefore, recovery after the contralateral secondary infarction was slower than that from the first, and received a lower recovery score compared to the recovery after the first infarction. These results suggest that the undamaged contralateral cortex plays an important role in motor recovery after hemiplegia caused by cerebral infarction.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/32947
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-7327
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal ; Vol. 12, 2013en
dc.subjectstrokeen
dc.subjectanimal modelen
dc.subjectrecoveryen
dc.subjectphotochemical infarctionen
dc.subject.ddc610
dc.titleContralateral cortical role on functional recovery in a rat model of hemiplegiaen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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