Novel activities of 1-adamantylthiopyridines as antibacterials, antimalarials and anticancers

Simple item page
dc.contributor.authorPrachayasittikul, Supaluk
dc.contributor.authorPrachayasittikul, Virapong
dc.contributor.authorRuchirawat, Somsak
dc.contributor.authorTreeratanapiboon, Lertyot
dc.date.accessioned2009-07-08T07:20:08Z
dc.date.available2009-07-08T07:20:08Z
dc.date.issued2009-07-08T07:20:08Z
dc.description.abstractTo discover new bioactive lead compounds for medicinal purposes, herein, 2(1-adamantylthio)pyridine and derivatives (1-10) were prepared and tested for antibacterial (agar dilution method against 27 strains of microorganisms), antimalarial (against Plasmodium falciparum) and anticancer (MOLT-3, HepG2, HuCCA-1 and A549) activities. Results showed that all the tested derivatives selectively exerted antigrowth activity against Streptococci at 15-30 µg/mL. 3-Substituted (R) thiopyridines; 3 (R = NAc2), 5 (R = OH) and 6 (R = Br) exhibited antibacterials, antimalarials and anticancers. Significantly, 6-(1-adamantylthio) nicotinonitrile (10) is a promising antibacterial which selectively displays antigrowth activity against Vibrio cholerae, Vibrio parahaemolyticus, Edwardsiella tarda and beta-hemolytic Streptococcus group A with minimum inhibitory concentration of 30 µg/mL. The findings reveal that these 1-adamantylthiopyridines represent a novel class of antibacterial, antimalarial and anticancer agents with potential medicinal values.en
dc.identifier.urihttp://hdl.handle.net/2003/26216
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-641
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal ; Vol. 8, 2009en
dc.subject1-adamantylthiopyridinesen
dc.subjectantibacterialen
dc.subjectanticancer activitiesen
dc.subjectantimalarialen
dc.subject.ddc610
dc.titleNovel activities of 1-adamantylthiopyridines as antibacterials, antimalarials and anticancersen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Prachayasittikul_novel_activities_proof.pdf
Size:
196.13 KB
Format:
Adobe Portable Document Format
Description:
DNB
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.02 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Original Articles