Macrophage migration inhibitory factor -173 G > C polymorphism and risk of tuberculosis
| dc.contributor.author | Naderi, Mohammad | |
| dc.contributor.author | Hashemi, Mohammad | |
| dc.contributor.author | Ansari, Hossein | |
| dc.date.accessioned | 2017-09-22T11:43:08Z | |
| dc.date.available | 2017-09-22T11:43:08Z | |
| dc.date.issued | 2017-03-21 | |
| dc.description.abstract | The aim of the present meta-analysis was to find out the impact of MIF -173 G > C polymorphism on risk of tuberculosis (TB). We conducted a search of case–control studies on the associations of -173 G > C variant of MIF with susceptibility to tuberculosis in PubMed, ISI Web of Science, and Scopus. We extracted the data from eligible studies and achieved a meta-analysis to examine the relationship between MIF -173 G > C polymorphism and the risk of TB. Odds ratios (ORs) with the corresponding 95 % confidence intervals (CIs) were pooled to find out the impact of MIF -173G > C promoter polymorphism on TB risk. The pooled ORs were calculated for the codomi- nant, dominant, recessive, and allelic model comparison. The findings revealed that MIF -173 G > C variant increased the risk of TB in codominant (OR = 1.54, 95 %CI = 1.26-1.88, p < 0.0001; CG vs GG), and dominant (OR = 1.62, 95 %CI = 1.33-1.96, p < 0.00001; GC+CC vs GG) inheritance models tested. The results suggested that the MIF -173 C allele significantly increased the risk of PTB (OR = 1.49, 95 %CI = 1.28-1.74, p < 0.00001). The findings of this meta-analysis propose that MIF -173 G > C variant is associated with the risk of TB. More case-control studies with well-designed in different ethnic groups and larger sample size are needed to confirm the findings. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/36103 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-18119 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal;Vol. 16 2017 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | MIF | en |
| dc.subject | Polymorphism | en |
| dc.subject | Tuberculosis | en |
| dc.subject | Meta-analysis | en |
| dc.subject.ddc | 610 | |
| dc.title | Macrophage migration inhibitory factor -173 G > C polymorphism and risk of tuberculosis | en |
| dc.title.alternative | a meta-analysis | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 | |
| eldorado.secondarypublication | true |