A meta-analysis of the relationship between body mass index and risk of rheumatoid arthritis
| dc.contributor.author | Zhou, Ying | |
| dc.contributor.author | Sun, Mingfang | |
| dc.date.accessioned | 2019-04-02T11:55:53Z | |
| dc.date.available | 2019-04-02T11:55:53Z | |
| dc.date.issued | 2018-11-06 | |
| dc.description.abstract | The present meta-analysis aimed to evaluate the relationship between body mass index (BMI) and rheumatoid arthritis (RA). A systematic search of the Cochrane, Pubmed, and Embase databases was conducted to identify relevant studies published before September 2017 using terms related to BMI and RA. Fixed or random-effect models were used to estimate the pooled relative risk (RR) with 95 % confidence interval (CI). Subgroup analyses by sex were performed to investigate the association between BMI and RA in male and female subgroups. A total of 14 eligible studies containing 353,948 patients were included in the analysis. The pooled results suggested that the odds ratios (ORs) of RA were 1.08 (95 % CI: 1.00~1.15) for overweight, and 1.32 (95 % CI: 1.11~1.54) for obesity, respectively, suggesting that a higher BMI increases the risk of RA compared to normal weight. Further subgroup analyses showed a positive association between BMI and RA risk but only in females, with a RR of 1.11 (95 % CI: 1.00~1.22) for overweight and 1.40 (95 % CI: 1.24~1.57) for obesity. In conclusion, an increased BMI may lead to a higher risk for RA development. Furthermore, the positive association between BMI and RA risk may be stronger in female populations than in males. However, additional analyses are needed. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/37976 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-19961 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal;Vol. 17 2018 | |
| dc.subject | Rheumatoid arthritis (RA) | en |
| dc.subject | Body mass index (BMI) | en |
| dc.subject | Meta-analysis | en |
| dc.subject | Risk factor | en |
| dc.subject.ddc | 610 | |
| dc.title | A meta-analysis of the relationship between body mass index and risk of rheumatoid arthritis | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 | |
| eldorado.secondarypublication | true |