Antiviral activity of flavonoids present in aerial parts of Marcetia taxifolia against Hepatitis B virus, Poliovirus, and Herpes Simplex Virus in vitro

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dc.contributor.authorOrtega, Joseph Thomas
dc.contributor.authorSerrano, María Luisa
dc.contributor.authorSuárez, Alírica Isabel
dc.contributor.authorBaptista, Jani
dc.contributor.authorPujol, Flor Helene
dc.contributor.authorCavallaro, Lucía Vicenta
dc.contributor.authorCampos, Héctor Rodolfo
dc.contributor.authorRangel, Héctor Rafael
dc.date.accessioned2020-05-19T07:44:52Z
dc.date.available2020-05-19T07:44:52Z
dc.date.issued2019-11-05
dc.description.abstractMarcetia taxifolia is a neotropical plant present in South America and it has been evaluated in several biological models due to the presence of active metabolites. Nevertheless, there is a limited quantity of studies related to the antiviral activity of the compounds present in this genus. In our work, the antiviral effect of the compounds isolated from the aerial parts of Marcetia taxifolia was evaluated against Hepatitis B virus (HBV), Herpes Simplex Virus type 1 (HSV-1), and Poliovirus type 1 (PV-1). The cytopathic effect and viral quantification by qPCR were determined as indicative of antiviral activity. Our data show that myricetin rhamnoside (MyrG), myricetin-3-α-O-ramnosil (1→6)-α-galactoside (MyrGG), 5,3'-dihydroxy-3,6,7,8,4’-pentamethoxyflavone (PMF), 5-hydroxy-3,6,7,3',4'pentamethoxyflavone (PMF-OH) had antiviral activity without cytotoxic effects. The methoxyflavones PMF and PMF-OH were the most active compounds, showing an antiviral effect against all the evaluated viruses. Computational studies showed that these compounds could interact with the Reverse Transcriptase. Altogether, these results suggest that the flavonoids (related to myricetin and methoxyflavones) are the main antiviral compounds present in the aerial parts of Marcetia taxifolia. Furthermore, our results showed that the methoxyflavones have a broad antiviral activity, which represents an opportunity to evaluate these flavonoids as lead molecules to develop new antiviral compounds.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/39109
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-21027
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 18 2019
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAntiviralen
dc.subjectFlavonoidsen
dc.subjectMarcetia taxifoliala
dc.subjectHBVen
dc.subjectHSVen
dc.subjectPolioen
dc.subject.ddc610
dc.titleAntiviral activity of flavonoids present in aerial parts of Marcetia taxifolia against Hepatitis B virus, Poliovirus, and Herpes Simplex Virus in vitroen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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