A sulfated polysaccharide of Ecklonia cava inhibits the growth of colon cancer cells by inducing apoptosis

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dc.contributor.authorAhna, Ginnae
dc.contributor.authorLee, WonWoo
dc.contributor.authorKim, Kil-Nam
dc.contributor.authorLee, Ji-Hyeok
dc.contributor.authorHeo, Soo-Jin
dc.contributor.authorKang, Nalae
dc.contributor.authorLee, Seung-Hong
dc.contributor.authorAhnf, Chang-Bum
dc.contributor.authorJeon, You-Jin
dc.date.accessioned2015-04-21T12:37:23Z
dc.date.available2015-04-21T12:37:23Z
dc.date.issued2015-02-24
dc.description.abstractWe investigated anticancer effects of the crude polysaccharides (CPs) isolated from Ecklonia cava enzymatic extracts using AMG, Viscozyme, Protamex, and Alcalase enzyme against a colon cancer cell line, CT26 cells. Among them, the CP of Protamex extract (PCP) contained the highest fucose and sulfated group contents and showed the highest growth inhibitory effect against CT-26 cells. In addition, PCP dose-dependently increased the formation of apoptotic body and the percentage of Sub-G1 DNA contents. Also, PCP activated caspase 9 and PARP as regulating the expressions of Bax and Bcl-2. Moreover, PPP2, a fraction purified from PCP showed the highest growth inhibitory effect against CT 26 cells with the increased fucose and sulfated group contents. The results demonstrate that the isolated SP containing plentiful fucose and sulfated group contents has the anticancer effect on colon cancer cells via regulation of Bcl-2/Bax signal pathway.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/34029
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-7279
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal ; Vol. 14, 2015en
dc.subjectEcklonia cavaen
dc.subjectsulfated polysaccharidesen
dc.subjectenzyme-assisted extractionen
dc.subjectapoptosisen
dc.subjectmurine colon cancer cells (CT-26 cells)en
dc.subject.ddc610
dc.titleA sulfated polysaccharide of Ecklonia cava inhibits the growth of colon cancer cells by inducing apoptosisen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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