Long-term administration of melatonin attenuates neuroinflammation in the aged mouse brain

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dc.contributor.authorPermpoonputtana, Kannika
dc.contributor.authorTangweerasing, Patlada
dc.contributor.authorMukda, Sujira
dc.contributor.authorBoontem, Parichart
dc.contributor.authorNopparat, Chutikorn
dc.contributor.authorGovitrapong, Piyarat
dc.date.accessioned2018-11-09T08:50:09Z
dc.date.available2018-11-09T08:50:09Z
dc.date.issued2018-07-02
dc.description.abstractAging is often accompanied by a decline in cognitive function in conjunction with a variety of neurobiological changes, including neuroinflammation. Melatonin is a key endogenous indoleamine secreted by the pineal gland that plays a crucial role in the regulation of circadian rhythms, is a potent free radical scavenger, has anti-inflammatory activity and serves numerous other functions. However, the role of melatonin in sterile inflammation in the brain has not been fully investigated. In the present study, we investigated the neuroinflammation status in aged mouse brains. The results showed that the protein levels of integrin αM (CD11b), glial fibrillary acidic protein (GFAP), the major pro-inflammatory cytokines (interleukin-1 beta [IL-1β], interleukin-6 [IL-6], and tumor necrosis factor alpha [TNF-α]) and phosphor-nuclear factor kappa B (pNFκB) were significantly increased, while Nmethyl- D-aspartate (NMDA) receptor subunits NR2A and NR2B, Ca2+/calmodulin-dependent protein kinase II (CaMKII), and brain-derived neurotrophic factor (BDNF) were down-regulated in the hippocampus and prefrontal cortex (PFC) of 22-months-old (aged) mice compared with 2-months-old (young adult) mice. Melatonin was administered in the drinking water to a cohort of the aged mice at a dose of 10 mg/kg/day, beginning at an age of 16 months for 6 months. Our results revealed that melatonin significantly attenuated the alterations in these protein levels. The present study suggests an advantageous role for melatonin in anti-inflammation, and this may lead to the prevention of memory impairment in aging.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/37651
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-19646
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 17 2018
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAgingen
dc.subjectNeuroinflammationen
dc.subjectMelatoninen
dc.subjectPro-inflammatory cytokineen
dc.subjectNFkBen
dc.subjectBDNFen
dc.subject.ddc610
dc.titleLong-term administration of melatonin attenuates neuroinflammation in the aged mouse brainen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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