Interleukin 6 (rs1800795) gene polymorphism is associated with cardiovascular diseases

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dc.contributor.authorGonzález-Castro, Thelma Beatriz
dc.contributor.authorHernández-Díaz, Yazmín
dc.contributor.authorPérez-Hernández, Nonanzit
dc.contributor.authorTovilla-Zárate, Carlos Alfonso
dc.contributor.authorJuárez-Rojop, Isela Esther
dc.contributor.authorLópez-Narvaez, María Lilia
dc.contributor.authorBlachman-Braun, Ruben
dc.contributor.authorPosadas-Sánchez, Rosalinda
dc.contributor.authorVargas-Alarcón, Gilberto
dc.contributor.authorGarcía-Flores, Esbeidy
dc.contributor.authorCazarín-Santos, Benny Giovanni
dc.contributor.authorBorgonio-Cuadra, Verónica Marusa
dc.contributor.authorReyes-López, Pedro A.
dc.contributor.authorRodríguez-Pérez, José Manuel
dc.date.accessioned2019-09-16T14:05:43Z
dc.date.available2019-09-16T14:05:43Z
dc.date.issued2019-06-07
dc.description.abstractCardiovascular diseases (CVD) are group of complex and multifactorial pathologies, in which interleukin-6 (IL- 6) gene polymorphisms have been associated with several components of the CVD. Thus, in this study, we thoroughly reviewed and meta-analyzed evidence on the association between the IL-6 (rs1800795) gene polymorphism and CVD. We systematically searched in the PubMed, Web of Sciences, and Scopus databases. The analyses were performed using five study groups based on (1) a combined pool of the overall populations, (2) the country of birth, (3) the continent of birth, (4) the diagnosis and (5) both location (country or continent) and diagnosis. The analysis included the allelic, homozygote, heterozygote, dominant and recessive models. The meta-analysisshowed that -174G>C (rs1800795) is a risk factor for CVD (allelic: OR=1.06, CI 95%=1.02-1.10. Z p value <0.0001; homozygous: OR=1.11, CI 95%=1.03-1.19, Z p value= 0.002; heterozygous: OR=1.08, CI 95%=1.03- 1.21, Z p value= 0.003; dominant: OR= 1.12, CI 95%= 1.07-1.18, Z p value= 0.001) and that this risk increases in the Chinese population. Additionally, we found that carriers of the C allele of 174G>C (rs1800795) polymorphism have an increase in the risk of coronary artery disease under the hereditary models assessed in the study. Using robust data, we found that IL-6 (rs1800795) -174G>C gene polymorphism is associated with CVD risk.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/38238
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-20208
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 18 2019
dc.subjectIL-6en
dc.subjectInflammationen
dc.subjectPolymorphismen
dc.subjectCardiovascular diseasesen
dc.subjectMeta-analysisen
dc.subjectGenetic associationen
dc.subject.ddc610
dc.titleInterleukin 6 (rs1800795) gene polymorphism is associated with cardiovascular diseasesen
dc.title.alternativea meta-analysis of 74 studies with 86,229 subjectsen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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