A Role for Integrin avß3 in Invasion Activity of Highly Metastatic Syrian Hamster Fibroblasts

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dc.contributor.authorBerman, A. E.de
dc.contributor.authorKozlova, N. E.de
dc.contributor.authorMorozevich, G. E.de
dc.date.accessioned2008-06-17T13:47:03Z
dc.date.available2008-06-17T13:47:03Z
dc.date.issued2004-12-09de
dc.description.abstractThe expression of extracellular matrix (ECM) specific receptors, integrins, was investigated in two closely related strains of oncogenically transformed fibroblasts drastically differing in spontaneous metastasizing. The highly metastatic cells (HM) were shown to express in their surface membranes much higher levels of collagen/vitronectin-specific integrin avß3, as compared to their lowly metastatic counterparts (LM). Inhibition of the avß3-mediated signal transduction strongly reduced the in vitro invasiveness of HM, whereas stimulation of avß3 signaling markedly augmented their invasive activity. The data obtained provide a direct evidence for implication of avß3 integrin in invasive phenotype of the oncotransformed fibroblasts.en
dc.identifier.issn1611-2156de
dc.identifier.urihttp://hdl.handle.net/2003/25641
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-119
dc.language.isoende
dc.relation.ispartofseriesEXCLI Journal ; Vol. 3, 2004en
dc.subjectfibroblastsen
dc.subjectintegrinsen
dc.subjectinvasionen
dc.subjectmetastasisen
dc.subjectoncotransformationen
dc.subject.ddc610
dc.titleA Role for Integrin avß3 in Invasion Activity of Highly Metastatic Syrian Hamster Fibroblastsen
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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