Distribution of polymorphic variants of CYP2A6 and their involvement in nicotine addiction

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dc.contributor.authorLópez-Flores, Luis A.
dc.contributor.authorPérez-Rubio, Gloria
dc.contributor.authorFalfán-Valencia, Ramcés
dc.date.accessioned2017-11-28T12:45:54Z
dc.date.available2017-11-28T12:45:54Z
dc.date.issued2017-03-06
dc.description.abstractTobacco consumption has become a major public health issue, which has motivated studies to identify and understand the biological processes involved in the smoking behavior for prevention and smoking cessation treatments. CYP2A6 has been identified as the main gene that codifies the enzyme that metabolizes nicotine. Many alleles have been identified after the discovery of CYP2A6, suggesting a wide interethnic variability and a diverse smoking behavior of the allele carrying individuals. The main purpose of this review is to update and highlight the effects of the CYP2A6 gene variability related to tobacco consumption reported from diverse human populations. The review further aims to consider CYP2A6 in future studies as a possible genetic marker for the prevention and treatment of nicotine addiction. Therefore, we analyzed several population studies and their importance at addressing and characterizing a population using specific parameters. Our efforts may contribute to a personalized system for detecting, preventing and treating populations at a higher risk of smoking to avoid diseases related to tobacco consumption.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/36216
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-18230
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 16 2017
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCYP2A6en
dc.subjectethnic differencesen
dc.subjectgenetic polymorphismen
dc.subjecttobacco consumptionen
dc.subjectnicotine metabolismen
dc.subjectnicotine addictionen
dc.subject.ddc610
dc.titleDistribution of polymorphic variants of CYP2A6 and their involvement in nicotine addictionen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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