Sodium valproate enhances urethane tumorigenicity in lungs of male but not female mice
| dc.contributor.author | Stakisaitis, Donatas | |
| dc.contributor.author | Uleckiene, Saule | |
| dc.contributor.author | Didziapetriene, Janina | |
| dc.contributor.author | Valanciute, Angelija | |
| dc.contributor.author | Mozuraite, Raminta | |
| dc.contributor.author | Matusevicius, Paulius | |
| dc.date.accessioned | 2014-11-24T08:27:04Z | |
| dc.date.available | 2014-11-24T08:27:04Z | |
| dc.date.issued | 2014-06-05 | |
| dc.description.abstract | In the study, the possible effect of sodium valproate (NaVP) on urethane-induced lung tumors in mice has been evaluated. BALB/c mice (n = 120; 4–6 weeks old, both sexes) were used in the following groups: 1) urethane-treated, 2) urethane–NaVP-treated, 3) only NaVP-treated, 4) control. In the same groups, castrated male mice (n = 48) were investigated. Urethane was given by intraperitoneal injections 10 mg/mouse, twice a week, the total dose 50 mg/mouse. In NaVP-treated mice, the 0.4 % NaVP aqueous solution was offered to mice ad libitum. The duration of the experiment was 6 months. The number of tumors per mouse in urethane–NaVP-treated males was significantly higher than in those treated with urethane only (13.82 ± 1.12 vs 6.77 ± 0.43, p < 0.0001). No significant difference in the number of tumors per mouse was revealed while comparing the female urethane- and urethane–NaVP-treated groups (6.50 ± 0.79 vs 8.15 ± 0.55, p = 0.105). No difference in the number of tumors per mouse was found in urethane–NaVP-treated castrated males as compared with urethane-treated castrated males. However, in the urethane–aVP-treated castrated males the number of tumors per mouse was significantly lower than in analogous non-castrated males (7.8 ± 1.67 vs 13.82 ± 1.12, p < 0.01). NaVP combined with urethane potentiates urethane tumorigenicity in BALB/c non-castrated but not in female and castrated male mice. These data indicate an important role of testosterone in the urethane-NaVP induced lung tumorigenesis. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/33693 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-6705 | |
| dc.language.iso | en | de |
| dc.relation.ispartofseries | EXCLI Journal ; Vol. 13, 2014 | en |
| dc.subject | sodium valproate | en |
| dc.subject | urethane | en |
| dc.subject | mice | en |
| dc.subject | lung tumorigenesis | en |
| dc.subject | gender differences | en |
| dc.subject.ddc | 610 | |
| dc.title | Sodium valproate enhances urethane tumorigenicity in lungs of male but not female mice | en |
| dc.type | Text | de |
| dc.type.publicationtype | article | de |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 |