Knockdown of lncRNA-PANDAR suppresses the proliferation, cell cycle and promotes apoptosis in thyroid cancer cells

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dc.contributor.authorLi, Zhirong
dc.contributor.authorGao, Bo
dc.contributor.authorHao, Shuai
dc.contributor.authorTian, Wuguo
dc.contributor.authorChen, Yi
dc.contributor.authorWang, Lingli
dc.contributor.authorZhang, Xiaohua
dc.contributor.authorLuo, Donglin
dc.date.accessioned2017-10-18T12:55:26Z
dc.date.available2017-10-18T12:55:26Z
dc.date.issued2017-03-23
dc.description.abstractLong non-coding RNAs (lncRNAs) have been found to show important regulatory roles in various human cancers. Lnc-RNA PANDAR is a novel identified lncRNA that was previously reported to show abnormal expression pattern in various cancers. However, little is known of its expression and biological function in thyroid cancer. Here, we used the quantitative real-time PCR (qRT-PCR) to determine the expression of PANDAR in 64 thyroid cancer tissues. We found that expression of PANDAR was up-regulated in thyroid cancer tissues compared with adjacent non-tumor tissues. Functional assays in vitro demonstrated that knockdown of PANDAR could inhibit proliferation, cell cycle progression, induces the apoptosis, inhibit invasion of thyroid cancer cells. Thus, our study provides evidence that PANDAR may function as a potential target for treatment for patients with thyroid cancer.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/36123
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-18139
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 16 2017
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectthyroid canceren
dc.subjectlncRNAsen
dc.subjectPANDARen
dc.subjectproliferationen
dc.subjectcell cycleen
dc.subjectapoptosisen
dc.subject.ddc610
dc.titleKnockdown of lncRNA-PANDAR suppresses the proliferation, cell cycle and promotes apoptosis in thyroid cancer cellsen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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