The effects of synbiotic supplementation on serum inflammatory markers and edema volume in breast cancer survivors with lymphedema

Simple item page
dc.contributor.authorVafa, Saeideh
dc.contributor.authorHaghighat, Shahpar
dc.contributor.authorJanani, Leila
dc.contributor.authorTotmaj, Ali Saneei
dc.contributor.authorNavaei, Mehraban
dc.contributor.authorAmirinejad, Ali
dc.contributor.authorEmamat, Hadi
dc.contributor.authorSalehi, Zahra
dc.contributor.authorZarrati, Mitra
dc.date.accessioned2020-05-25T14:06:23Z
dc.date.available2020-05-25T14:06:23Z
dc.date.issued2020-01-02
dc.description.abstractBreast cancer-related lymphedema (BCRL) is one of the most common complications of breast cancer treatments, which may be exacerbated by obesity. Dysbiosis may negatively impact the management of obesity and lymphedema by increasing inflammation. The objective of this study was to assess the effects of supplementation with synbiotics on inflammatory markers, serum leptin concentration and edema volume in overweight and obese BCRL women following a low-calorie diet (LCD). In a randomized double-blind controlled clinical trial, 88 breast cancer survivors with lymphedema were supplemented once a day for 10 weeks with either a synbiotic or a placebo capsule. Both groups were under a low-calorie diet (LCD). At the end of the study, synbiotic supplementation resulted in a significant reduction in leptin (P=0.003) and TNF-α (P=0.039) between the study groups. Besides, edema volume was significantly reduced within the synbiotic group after the intervention. We did not observe any significant effects of the synbiotic supplementation in hs-CRP, and IL-1β between the study groups (P=0.550, P=0.118 respectively). Conclusively, synbiotic supplementation along with an LCD program in breast cancer survivors with lymphedema had beneficial effects on the concentration of serum inflammatory markers and edema volume.de
dc.identifier.urihttp://hdl.handle.net/2003/39143
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-21061
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol.19.2020, p.1-15
dc.subjectInflammationde
dc.subjectBreast cancerde
dc.subjectLymphedemade
dc.subjectProbioticde
dc.subjectPrebioticde
dc.subjectCaloric restrictionde
dc.subject.ddc610
dc.titleThe effects of synbiotic supplementation on serum inflammatory markers and edema volume in breast cancer survivors with lymphedemade
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Zarrati_Haghighat_02012020_proof.pdf
Size:
426.08 KB
Format:
Adobe Portable Document Format
Description:
DNB
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.85 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Original Articles 2020