Protective effect of ginseng against gamma-irradiation-induced oxidative stress and endothelial dysfunction in rats
| dc.contributor.author | Mansour, Heba Hosny | |
| dc.date.accessioned | 2014-03-11T09:20:47Z | |
| dc.date.available | 2014-03-11T09:20:47Z | |
| dc.date.issued | 2013-08-30 | |
| dc.description.abstract | This study investigated the potential protective effects of ginseng on gamma-irradiation-induced oxidative stress and endothelial dysfunction in rats. Twenty four male albino rats were divided into four groups. In the control group, rats were administered vehicle by tube for 7 consecutive days. The second group was administered ginseng extract (100 mg/kg, by gavage) for 7 consecutive days. Animals in the third group were administered vehicle by tube for 7 consecutive days, then exposed to single dose gamma-irradiation (6 Gy). The Fourth group received ginseng extract for 7 consecutive days, one hour later rats were exposed to gamma-irradiation. Oral administration of ginseng extract prior to irradiation produced a significant protection which was evidenced by a significant reduction in serum creatine kinase (CPK) and lactate dehydrogenase (LDH) activities and asymmetric dimethylarginine (ADMA), urea and creatinine levels with significant increase in serum total nitrate/nitrite (NO(x)) level. Moreover, ginseng significantly increased cardiac and renal superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) activities, and reduced glutathione (GSH) content, associated with a significant depletion in malondialdehyde (MDA) and NO(x) levels compared to irradiated group. This study suggests that ginseng may serve as a potential protective agent against gamma-irradiation-induced cardio-nephrotoxicity via enhancing the antioxidant activity and inhibition of endothelial dysfunction. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/32957 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-7361 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal ; Vol. 12, 2013 | en |
| dc.subject | ginseng | en |
| dc.subject | gamma-radiation | en |
| dc.subject | asymmetric dimethylarginine | en |
| dc.subject | nitric oxide | en |
| dc.subject | oxidative stress | en |
| dc.subject | rats | de |
| dc.subject.ddc | 610 | |
| dc.title | Protective effect of ginseng against gamma-irradiation-induced oxidative stress and endothelial dysfunction in rats | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 |