Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury
| dc.contributor.author | Ahmadi, Mahboubeh Yeganeh Haj | |
| dc.contributor.author | Badinloo, Marziyeh | |
| dc.contributor.author | Joukar, Siyavash | |
| dc.contributor.author | Mirzaeipour, Fateme | |
| dc.contributor.author | Najafipour, Hamid | |
| dc.contributor.author | Nasri, Hamidreza | |
| dc.date.accessioned | 2013-05-23T12:48:24Z | |
| dc.date.available | 2013-05-23T12:48:24Z | |
| dc.date.issued | 2013-05-23 | |
| dc.description.abstract | Administration of semelil (ANGIPARS™) has been successful in the treatment of diabetic foot ulcer. Considering the improvement of blood flow and anti-inflammatory effect that are attributed to this drug, we investigated its effect on cardiovascular performance in rabbits with isoproterenol (ISO) induced myocardial injury. Animal groups included: control group; ISO group, received ISO 50 mg/kg s.c. for two consecutive days; S1+ISO, S5+ISO and S10+ISO groups, received semelil 1, 5, and 10 mg/kg/day i.p. respectively, 30 min before ISO. On the 3rd day, electrocardiogram (ECG) and hemodynamic parameters were recorded; blood samples were taken and hearts were removed for lab investigations. ISO induced heart injury, ECG disturbance, raise of cardiac troponin I and significant decrease in LVSP (p<0.05), +dp/dt max (p<0.01), -dp/dt max (p<0.05) along with increase of LVEDP (p<0.01). Semelil had no significant effects on ECG and plasma cardiac troponin I. Impairment of +dp/dt max and -dp/dt max was significantly improved in S5+ISO and S10+ISO groups (P<0.05 versus ISO). In addition, LVSP and LVEDP was somewhat recovered in these groups, although semelil (1 mg/kg/day) to some extent exacerbated the myocardial lesions induced by ISO (P<0.05). Therefore, in stressful conditions, semelil may improve myocardial contractility; however, it may aggravate the severity of injury. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/30343 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-5400 | |
| dc.language.iso | en | de |
| dc.relation.ispartofseries | EXCLI Journal ; Vol. 12, 2013 | en |
| dc.subject | arterial blood pressure | en |
| dc.subject | heart function | en |
| dc.subject | isoproterenol | en |
| dc.subject | myocardial injury | en |
| dc.subject | semelil | en |
| dc.subject.ddc | 610 | |
| dc.title | Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury | en |
| dc.type | Text | de |
| dc.type.publicationtype | article | de |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 |