Inheritance involved in the pathogenesis of idiopathic scoliosis
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Date
2008-04-22
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Abstract
Idiopathic scoliosis is a common cause of spinal deformity in children and adolescents. Although
the incidence of the scoliosis is up to 2 %-3 % of the world’s population, the pathogenesis
is still obscure. Recent evidences show that the disease has a hereditary basis. Clinical
manifestations as well as family studies reveal the familial tendency of idiopathic scoliosis,
and support that the heredity is an important cause of this disease. Many related genes, such
as SNTGI and CHD7, are believed to play a role in the development of idiopathic scoliosis
but the underlying mechanism is still not clear. This review focus on the mode of inheritance
of idiopathic scoliosis and some related molecules.
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Keywords
genetics, idiopathic scoliosis