Macrophage migration inhibitory factor -173 G/C polymorphism is associated with an increased risk of pulmonary tuberculosis in Zahedan, Southeast Iran

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dc.contributor.authorHashemi, Mohammad
dc.contributor.authorSharifi-Mood, Batool
dc.contributor.authorRasouli, Azam
dc.contributor.authorAmininia, Shadi
dc.contributor.authorNaderi, Mohammad
dc.contributor.authorTaheri, Mohsen
dc.date.accessioned2015-04-21T12:39:53Z
dc.date.available2015-04-21T12:39:53Z
dc.date.issued2015-01-21
dc.description.abstractMacrophage migration inhibitory factor (MIF) has an important role in controlling infection. The aim of this study was to evaluate the possible association between MIF -173 G/C functional polymorphism and pulmonary tuberculosis (PTB) in an Iranian population from Zahedan Southeast Iran. This case-control study was done on 161 PTB and 142 healthy subjects. Genomic DNA was extracted from all participants by salting out method. The MIF -173 G/C variant was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The finding showed that the MIF -173 G/C polymorphism increased the risk of PTB in codominant (OR=1.76, 95 % CI=1.05-2.95, p=0.038, GC vs GG) and dominant (OR=1.78, 95 % CI=1.09-2.91, p=0.027, GC+CC vs GG) tested inheritance models. Furthermore, the minor allele frequency (MAF) increased the risk of PTB in comparison with G allele (OR=1.63, 95 % CI=1.07-2.48, p=0.028). In conclusion, the present study provides evidence that -173 G/C polymorphism may increase the risk of PTB.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/34032
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-7597
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal ; Vol. 14, 2015en
dc.subjectTuberculosisen
dc.subjectmacrophage migration inhibitory factoren
dc.subjectMIFen
dc.subjectpolymorphismen
dc.subject.ddc610
dc.titleMacrophage migration inhibitory factor -173 G/C polymorphism is associated with an increased risk of pulmonary tuberculosis in Zahedan, Southeast Iranen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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