Antimalarial and antimicrobial activities of 8-aminoquinoline-uracils metal complexes

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dc.contributor.authorPhopin, Kamonrat
dc.contributor.authorSinthupoom, Nujarin
dc.contributor.authorTreeratanapiboon, Lertyot
dc.contributor.authorKunwittaya, Sarun
dc.contributor.authorPrachayasittikul, Supaluk
dc.contributor.authorRuchirawat, Somsak
dc.contributor.authorPrachayasittikul, Virapong
dc.date.accessioned2016-06-13T09:26:00Z
dc.date.available2016-06-13T09:26:00Z
dc.date.issued2016-02-18
dc.description.abstract8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5 (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including P. shigelloides and S. dysenteriae. The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.en
dc.identifier.doi10.17179/excli2016-101
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/35089
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-17137
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 15, 2016
dc.rights.urihttp://creativecommons.org/licenses/by/4.0
dc.subjectaminoquinolineen
dc.subjectmetal complexesen
dc.subjecturacilsen
dc.subjectantimicrobialen
dc.subjectantimalarialen
dc.subject.ddc610
dc.titleAntimalarial and antimicrobial activities of 8-aminoquinoline-uracils metal complexesen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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