Eldorado - Repository of the TU Dortmund

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Amtliche Mitteilungen der Technischen Universität Dortmund Nr. 4/2026
(Technische Universität Dortmund, 2026-02-05)
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Predicting later advanced language and metacognitive skills from initiations of joint interaction and communicative goals in earlier development
(2025) Crawshaw, Camilla; Ritterfeld, Ute; Lüke, Carina
Diese kumulative Dissertation untersuchte die Fähigkeiten von Kindern in Bezug auf Gestik, Sprache, Theory of Mind (ToM) und Metaphernverständnis im Rahmen einer umfassenderen Längsschnittstudie, wobei sowohl Längsschnitt- als auch Querschnittsperspektiven berücksichtigt und etwaige Sprachentwicklungsverzögerungen untersucht wurden. Die Ergebnisse zeigten, dass die Fähigkeit, im Alter von 12 Monaten gezielt mit dem Zeigefinger zu zeigen, das Metaphernverständnis der Kinder 8 Jahre später direkt vorhersagen konnte. Dieses frühe Zeigen mit dem Zeigefinger konnte indirekt einige Sprachfähigkeiten, ToM und Metaphernverständnis im Alter von 9 Jahren über zwei Mediationswege (Verständnis ikonischer Gesten und Sprachfähigkeiten im Alter von 3 Jahren) vorhersagen. Kinder, die ‚Late Talkers‘ waren, zeigten in einigen Sprachmessungen, im fortgeschrittenen ToM und im Metaphernverständnis unterschiedliche Leistungen. Das frühe Erzeugen und Verstehen von Gesten könnte somit nicht nur die Entwicklung der Sprachfähigkeiten von Kindern unterstützen und fördern, sondern auch ihre Fähigkeiten zum ToM und zum Metaphernverständnis.
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Traces of gravity
(2025) Krieg, Sara; Päs, Heinrich; Hiller, Gudrun
The guiding idea of this thesis is to investigate how subtle traces of gravity manifest themselves across different scales. First, we examine whether the Cohen, Kaplan and Nelson (CKN) bound can form the basis of a consistent cosmological model and whether such a model is favored by observational data, in particular the recent baryonic acoustic oscillation measurements from the Dark Energy Spectroscopic Instrument. Taking into account additional late-universe measurements, there is a mild preference for the (𝜈)CKN model over the standard 𝛬CDM scenario with cold dark matter and a cosmological constant. However, once weak lensing and cosmological microwave background data are included and the early-time dynamics are accounted for, the resulting bounds on the model parameter 𝜈 restrict the (𝜈)CKN model to a regime in which the (𝜈)CKN framework is observationally indistinguishable from 𝛬CDM. Second, we develop an internal wave packet formalism for neutrino oscillations in weakly curved spacetimes. Gravitational corrections appear as phase modifications, but these effects lie far beyond current experimental sensitivity. Importantly, if deviations from expected oscillation patterns are observed, classical gravity can be ruled out as their source, thereby pointing to new physics beyond the Standard Model, such as quantum gravity. Finally, we employ the open quantum system framework to model Quantum Gravity (QG)-induced decoherence of high-energy neutrinos and perform a sensitivity analysis using IceCube data. Using current experimental data we also derive bounds on the damping parameter 𝛾0 for different energy scalings and obtain the first constraints for scenarios involving additional dark fermions.
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Foldseek reveals a CBGA prenylating enzyme GlyMa_02G168000 from Glycine max
(2024-01-04) Jordan, Erin Noel; Schmidt, Christina; Kayser, Oliver
The present research provides an application for an aromatic prenyltransferase from Glycine max for use in heterologous microorganism expression to generate cannabinoids. The known cannabinoid prenyltransferase CsPT04 was queried in FoldSeek. An enzyme derived from Glycine max known as GLYMA_02G168000, which is a predicted homogentisate solanyltransferase, was identified and found to have affinity for the prenylation of geranyldiphosphate (GPP) and olivetolic acid (OA) to produce cannabigerolic acid (CBGA) and cannabigerol (CBG). The in vitro production of CBGA was accomplished through the heterologous expression of this prenyltransferase in Saccharomyces cerevisiae. After growing the yeast cells, a purified microsomal fraction was harvested, which was rich in the membrane-bound prenyltransferase GlyMa_02G168000. Addition of purified microsomal fraction to a reaction matrix facilitated the successful prenylation of externally supplied OA with GPP, culminating in the production of CBGA. Structural comparisons revealed a notably closer similarity between GLYMA_02G168000 and CsPT04, compared to the similarity of other cannabinoid prenyltransferases with CsPT04. Herein, a novel application for a homogentisate solanyltransferase has been established towards the production of cannabinoids.