Eldorado - Repositorium der TU Dortmund

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Bei diesem Service handelt es sich um das Institutionelle Repositorium der Technischen Universität Dortmund. Hier werden Ressourcen aus und für Lehre, Studium und Forschung gespeichert, erschlossen und der Öffentlichkeit zugänglich gemacht.

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Aktuellste Veröffentlichungen

Ontology-based temporal querying for assessing safety-critical scenarios in road traffic
(2026) Westhofen, Lukas; Neider, Daniel; Fränzle, Martin
The dissertation is the first to push temporal querying over expressive Description Logics towards practical applicability. Performance is of specific importance, albeit challenging given that the underlying problem is ExpTime-complete. We thus explore multiple approaches and optimizations for enabling well-performing ontology-based temporal data access. While a first procedure compiles the temporal aspects into a finite automaton, we observe that - even in an optimized version - inefficient disjunctive queries are sometimes unnecessarily checked. A second, orthogonal algorithm therefore proposes to skip the automaton and instead operate directly on the query by means of a normal form. As the goal is to establish practical applicability, we finally broaden the evaluation towards embedding temporal querying into a third-party scenario-based test coverage framework.
Kindertagesbetreuung NRW 2026
(2026) Gossen, Jakob; Lange, Mirja; Queißer-Schlade, Yvonne; Wahlers , Lena Katharina
Prozesswechselwirkungen beim Microfinishen von Funktionsflächen rotationssymmetrischer Bauteile
(2026) Tilger, Meik; Biermann, Dirk; Heinzel, Carsten
Das Funktionsverhalten gleit-reibbeanspruchter Oberflächen wird durch viele unterschiedliche Eigenschaften und Parameter, wie zum Beispiel die Kontaktverhältnisse und Reibungsart, aber auch die Oberflächentopographie und -integrität der Kontaktpartner beeinflusst. Diese werden meist durch eine mechanische Bearbeitung konditioniert. Hierzu zählen auch Honverfahren, wie das Microfinishen, auch Kurzhubhonen oder Superfinishen genannt, das ein relevantes Bearbeitungsverfahren zur Herstellung gleit-reibbeanspruchter Oberflächen ist. Im Rahmen der vorliegenden Arbeit wird das Microfinishen mit Band unter Berücksichtigung des elastischen Werkzeugverhaltens betrachtet. Hierbei wird für unterschiedliche Andrückelemente die Kontaktzone und die daraus resultierende Flächenpressung zwischen Werkzeug und Werkstück sowie deren Einfluss auf die Prozesswechselwirkungen untersucht. Auf Basis gezielt angepasster flexibler Federstahl-Andrückelemente wird analysiert, ob sich die unterschiedlichen Anforderungen hinsichtlich radialer Welligkeit, axialer Kontur und Bauteiltopographie mittels Microfinishen mit Band erreichen lassen. Ziel der Betrachtungen ist es, die Herstellung von technischen Funktionsflächen mittels Microfinishen genauer zu verstehen und auf Basis der Erkenntnisse Handlungsempfehlungen zu geben, um die Prozessauslegung zur Herstellung technischer Funktionsflächen zu optimieren.
Integrative analysis of dynamic allostery and hydration networks in p38α Map kinase using Nuclear Magnetic Resonance and molecular dynamics simulations
(2026) Roy Acharyya, Suchandra; Linser, Rasmus; Bernardi, Rafael C.
Protein kinases are major therapeutic targets, but the high conservation of their ATP-binding sites limits the development of selective inhibitors. This has increased interest in kinase conformational ensembles and long-range allosteric communication as alternative routes for selective modulation. Here, p38α MAP kinase was used as a model system to investigate how dynamic communication across the kinase domain regulates structure, stability, hydration, and ligand response. Large-scale molecular dynamics simulations combined with dynamical network analysis identified key residues that mediate communication between the N- and C-lobes and connect functional regions including the activation loop, hinge, lipid-binding domain, and cryptic allosteric pocket. These predictions were experimentally tested using NMR spectroscopy, biochemical activity assays, and selected p38α mutants in the presence and absence of an active-site inhibitor. A second part of the study focused on Asp168, the conserved aspartate of the DFG motif, which is essential for catalytic activity and activation-loop organisation. Mutation of this residue induced long-range effects beyond the active site, altering thermal stability, residue-level flexibility, cross-lobe correlations, ligand behaviour, and hydration networks in distal pockets. In particular, D168A reorganised water-associated signals around the activation loop and lipid pocket, obtained through experimental solution and solid-state NMR and bolstered by molecular dynamics simulations, demonstrating that perturbation of a catalytic DFG residue can reshape both protein dynamics and solvent organisation across the kinase domain. Together, these results provide atomistic insight into how local perturbations propagate through p38α to regulate allosteric communication. This integrated computational and experimental structural-biology framework to understand the dynamic allostery functioning within the kinase may guide the rational design of selective allosteric kinase modulators that exploit dynamic and hydration-mediated regulatory networks rather than conserved active-site features alone.
Enhanced superconductivity in proximity to peaks in densities of states
(arXiv, 2026-09-08) Althüser, Joshua; Eremin, Ilya M.; Uhrig, Götz S.
For the BCS theory of superconductivity, the electron-phonon interaction is transformed to an attractive electron-electron interaction in the vicinity of the Fermi energy only. At the same time, its formal derivation using a unitary transformation reveals that the electrons attract one another whenever their energies do not differ by more than the phonon energy 𝜔D , independent of closeness to the Fermi energy. Consequently, the order parameter becomes finite even away from the Fermi level. Yet, for small interactions, its magnitude is usually small and can be safely ignored, justifying the BCS approximation. Intriguingly, we find that an accumulation of density of states at an energy ɛpeak in proximity to the Fermi energy induces a significant order parameter magnitude around ɛpeak , which exceeds the one at 𝐸F for moderate coupling strengths. This strong enhancement is heralded by the softening of an additional collective mode, which resembles a second phase transition. We predict measurable signatures in the thermodynamic and spectroscopic responses to this unexpected phenomenon, guiding future experimental searches for it. Finally, we demonstrate that these signatures remain robust upon including a phenomenological Coulomb repulsion, indicating that the enhancement is not an artifact of the idealized model.